Evidence map›Paper›PMID 28630292›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.

Ian Cook, Ting Wang, Thomas S Leyh

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  4. Review
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  9. Article
  10. Genetic and Neurological Deficiencies in the Visual System ofInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. The Human UGT2B7 Nanodisc.Drug metabolism and disposition: the biological fate of chemicals · 2020
    Article
  13. Allosteres to regulate neurotransmitter sulfonation.The Journal of biological chemistry · 2019
    Article
  14. Article
  15. Article
  16. The NSAID allosteric site of human cytosolic sulfotransferases.The Journal of biological chemistry · 2017
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ian CookDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461-1926.
Ting WangDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461-1926.
Thomas S LeyhDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461-1926 tom.leyh@einstein.yu.edu.
Albert Einstein College of Medicine · US

Funding

Sulfotransferase Specificity and the Development of Sulfation Resistant CompoundsR01GM106158 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LEYH, THOMAS S. · 2014 to 2016
$1.1M
Allosteric Regulation of Human Cytosolic SulfotransferasesR01GM121849 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LEYH, THOMAS S. · 2017 to 2018
$888k
NIGMS NIH HHS R01 GM106158NIGMS NIH HHS R01 GM121849
6 · The paper itself

Abstract

Monoamine neurotransmitters are among the hundreds of signaling small molecules whose target interactions are switched "on" and "off" via transfer of the sulfuryl-moiety (-SO

Indexed as

Allosteric SiteAminesArylsulfotransferaseBinding SitesBiopterinsEscherichia coliGenetic VectorsHumansIsoenzymesKineticsMagnetic Resonance SpectroscopyMolecular Dynamics SimulationNeurotransmitter AgentsProtein BindingSoftwareSulfurAminesArylsulfotransferaseBiopterinsIsoenzymesmonoamine-sulfating phenol sulfotransferaseNeurotransmitter AgentssapropterinSulfurallosteryevolutionneurotransmittersulfotransferasetetrahydrobiopterin

Identifiers

PMID28630292
PMCPMC5502633
OpenAlexW2650236953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.