Evidence map›Paper›PMID 28630263›Full record

ArticleMolecular pharmacology2017

Determination of the Residues in the Extracellular Domain of the Nicotinic

Xiaochun Jin, Allison L Germann, Daniel J Shin, Gustav Akk, Joe Henry Steinbach

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiaochun JinDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri (X.J., A.L.G., D.J.S., G.A., J.H.S.); and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri (G.A., J.H.S.).
Allison L GermannDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri (X.J., A.L.G., D.J.S., G.A., J.H.S.); and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri (G.A., J.H.S.).
Daniel J ShinDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri (X.J., A.L.G., D.J.S., G.A., J.H.S.); and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri (G.A., J.H.S.).
Gustav AkkDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri (X.J., A.L.G., D.J.S., G.A., J.H.S.); and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri (G.A., J.H.S.).
Joe Henry SteinbachDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri (X.J., A.L.G., D.J.S., G.A., J.H.S.); and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis, St. Louis, Missouri (G.A., J.H.S.) jhs@morpheus.wustl.edu.
Taylor Family Institute for Innovative Psychiatric ResearchWashington University in St. Louis · US

Funding

Aceytylcholine Receptor FunctionR01NS022356 · NINDS · WASHINGTON UNIVERSITY · PI STEINBACH, JOSEPH H. · 1985 to 2013
$3.8M
SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580NINDS NIH HHS R01 NS022356
6 · The paper itself

Abstract

Physostigmine can potentiate and inhibit neuronal nicotinic receptors, in addition to inhibiting the activity of acetylcholinesterase. We found that receptors containing three copies of the

Indexed as

AnimalsHumansMiceNicotinic AntagonistsPhysostigmineProtein DomainsProtein SubunitsReceptors, NicotinicStructure-Activity RelationshipXenopus laevisNicotinic AntagonistsPhysostigmineProtein SubunitsReceptors, Nicotinic

Identifiers

PMID28630263
PMCPMC5548365
OpenAlexW2662282141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.