Evidence map›Paper›PMID 28630260›Full record

ArticleJournal of lipid research2017

Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine.

Shunxing Rong, Jeffrey G McDonald, Luke J Engelking

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shunxing RongDepartments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.
Jeffrey G McDonaldDepartments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.
Luke J EngelkingDepartments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046 luke.engelking@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
SREBP-Mediated Lipid Regulation in the IntestineK08DK102652 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ENGELKING, LUKE JAMES · 2014 to 2018
$755k
NHLBI NIH HHS P01 HL020948NIDDK NIH HHS K08 DK102652
6 · The paper itself

Abstract

SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (

Indexed as

AnimalsCholesterolCholesterol, DietaryEzetimibeGene DeletionIntestinal DiseasesIntestinal MucosaIntestinesMiceSterol Regulatory Element Binding Protein 2CholesterolCholesterol, DietaryEzetimibeSrebf2 protein, mouseSterol Regulatory Element Binding Protein 2cholesterol/biosynthesisfatty acid/synthesisNiemann-Pick C1-like 1organoidScapSREBP

Identifiers

PMID28630260
PMCPMC5625122
OpenAlexW2656341959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.