ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Cold-Induced Thermogenesis and Inflammation-Associated Cold-Seeking Behavior Are Represented by Different Dorsomedial Hypothalamic Sites: A Three-Dimensional Functional Topography Study in Conscious Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms.iScience · 2026Article
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- LPS mediated neuronal c-Fos activation: whole-brain mapping, site and time effect in intoxicated mice.Toxicology research · 2025Article
- Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock.British journal of pharmacology · 2025Article
- Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation.Frontiers in immunology · 2025Article
- Core body temperatures of rats subjected to treadmill exercise to fatigue or exhaustion: The journalTemperature (Austin, Tex.) · 2023Article
- Selection of preferred thermal environment and cold-avoidance responses in rats rely on signals transduced by the dorsal portion of the lateral funiculus of the spinal cord.Temperature (Austin, Tex.) · 2023Article
- How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress.Temperature (Austin, Tex.) · 2023Review
- LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Role of TRPM8 in switching between fever and hypothermia in adult mice during endotoxin-induced inflammation.Brain, behavior, & immunity - health · 2021Article
- Physiological and Behavioral Mechanisms of Thermoregulation in Mammals.Animals : an open access journal from MDPI · 2021Review
- Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat.Scientific reports · 2020Article
- Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities.Journal of medicinal chemistry · 2020Article
- Diet-induced obesity attenuates the hypothermic response to lipopolysaccharide independently of TNF-α production.Temperature (Austin, Tex.) · 2020Article
- Neurons in the rat ventral lateral preoptic area are essential for the warm-evoked inhibition of brown adipose tissue and shivering thermogenesis.Acta physiologica (Oxford, England) · 2019Article
- Preoptic area cooling increases the sympathetic outflow to brown adipose tissue and brown adipose tissue thermogenesis.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Activation of adenosine ANeuropharmacology · 2018Article
- Inflammation-induced motivational changes: Perspective gained by evaluating positive and negative valence systems.Current opinion in behavioral sciences · 2018Article
- Neural Mechanisms of Inflammation-Induced Fever.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development.Acta physiologica (Oxford, England) · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In the past, we showed that large electrolytic lesions of the dorsomedial hypothalamus (DMH) promoted hypothermia in cold-exposed restrained rats, but attenuated hypothermia in rats challenged with a high dose of bacterial lipopolysaccharide (LPS) in a thermogradient apparatus. The goal of this study was to identify the thermoeffector mechanisms and DMH representation of the two phenomena and thus to understand how the same lesion could produce two opposite effects on body temperature. We found that the permissive effect of large electrolytic DMH lesions on cold-induced hypothermia was due to suppressed thermogenesis. DMH-lesioned rats also could not develop fever autonomically: they did not increase thermogenesis in response to a low, pyrogenic dose of LPS (10 μg/kg, i.v.). In contrast, changes in thermogenesis were uninvolved in the attenuation of the hypothermic response to a high, shock-inducing dose of LPS (5000 μg/kg, i.v.); this attenuation was due to a blockade of cold-seeking behavior. To compile DMH maps for the autonomic cold defense and for the cold-seeking response to LPS, we studied rats with small thermal lesions in different parts of the DMH. Cold thermogenesis had the highest representation in the dorsal hypothalamic area. Cold seeking was represented by a site at the ventral border of the dorsomedial nucleus. Because LPS causes both fever and hypothermia, we originally thought that the DMH contained a single thermoregulatory site that worked as a fever-hypothermia switch. Instead, we have found two separate sites: one that drives thermogenesis and the other, previously unknown, that drives inflammation-associated cold seeking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.