ArticleBMJ case reports2017
QUAD fever: beware of non-infectious fever in high spinal cord injuries.
Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- From profound hypothermia to malignant hyperpyrexia: a case report of biphasic thermoregulatory crisis following acute high cervical spinal cord injury.BMC neurology · 2026Article
- Article
- Unraveling quad fever: Severe hyperthermia after traumatic cervical spinal cord injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2023Article
- Expert's comment concerning Grand Rounds case entitled "Pure distraction injury of T1-2 with quad fever" by Jun-Yeong Seo et al. (Eur Spine J [2017]: doi:10.1007/s00586-017-5232-2).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A case of cervical spinal cord injury and quadriparesis with prolonged fever is being described. Initially, the patient received treatment for well-documented catheter-related bloodstream infection. High spiking fever returned and persisted with no obvious evidence of infection. The usual non-infectious causes too were carefully excluded. QUAD fever or fever due to spinal cord injury itself was considered. The pathogenetic basis of QUAD fever is unclear but could be attributed to autonomic dysfunction and temperature dysregulation. Awareness of this little known condition could help in avoiding unnecessary antimicrobial therapy and in more accurate prognostication. Unlike several previous reported cases that ended fatally, the present case ran a relatively benign course. The spectrum of presentations may therefore be broader than hitherto appreciated.
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