Evidence map›Paper›PMID 28630201›Full record

ArticleAntimicrobial agents and chemotherapy2017

Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics.

Kevin K Pakula, Lykke H Hansen, Birte Vester

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kevin K PakulaDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Lykke H HansenDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Birte VesterDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark b.vester@bmb.sdu.dk.ORCID 0000-0002-5368-0500
University of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several groups of antibiotics inhibit bacterial growth by binding to bacterial ribosomes. Mutations in ribosomal protein L3 have been associated with resistance to linezolid and tiamulin, which both bind at the peptidyl transferase center in the ribosome. Resistance to these and other antibiotics also occurs through methylation of 23S rRNA at position A2503 by the methyltransferase Cfr. The mutations in L3 and the

Indexed as

Anti-Bacterial AgentsBacterial ProteinsDrug Resistance, BacterialEscherichia coliMethyltransferasesMicrobial Sensitivity TestsMutationPeptidyl TransferasesPlasmidsRibosomal Protein L3Ribosomal ProteinsRibosomesRNA, Ribosomal, 23SAnti-Bacterial AgentsBacterial ProteinsMethyltransferasesPeptidyl TransferasesRibosomal Protein L3Ribosomal ProteinsRNA, Ribosomal, 23Santibiotic resistanceCfrL3 mutationslinezolid resistancetiamulin resistance

Identifiers

PMID28630201
PMCPMC5571294
OpenAlexW2674261761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.