Evidence map›Paper›PMID 28630169›Full record

ArticleCirculation. Arrhythmia and electrophysiology2017

Patient-Specific Drug Screening Using a Human Induced Pluripotent Stem Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Type 2.

Leonid Maizels, Irit Huber, Gil Arbel, Anke J Tijsen, Amira Gepstein, Asaad Khoury, Lior Gepstein

Open access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leonid MaizelsFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.).
Irit HuberFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.).
Gil ArbelFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.).
Anke J TijsenFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.).
Amira GepsteinFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.).
Asaad KhouryFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.).
Lior GepsteinFrom the Rappaport Faculty of Medicine and Research Institute (L.M., I.H., G.A., A.J.T., A.G., L.G.); and Rambam Health Care Campus; Technion-Institute of Technology; Haifa, Israel (A.K., L.G.). mdlior@tx.technion.ac.il.
Technion – Israel Institute of Technology · ILRambam Health Care Campus · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCatecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) results from autosomal recessive METHODS AND

resultshiPSC cardiomyocytes were derived from a CPVT2 patient (D307H-

conclusionsThese results demonstrate the ability of hiPSCs cardiomyocytes to recapitulate CPVT2 disease phenotype and drug response in the culture dish, to provide novel insights into disease and drug therapy mechanisms, and potentially to tailor patient-specific drug therapy.

Indexed as

Precision MedicineAction PotentialsAdrenergic AgonistsAnti-Arrhythmia AgentsCalcium SignalingCalsequestrinCase-Control StudiesCell LineDose-Response Relationship, DrugGenetic Predisposition to DiseaseHumansInduced Pluripotent Stem CellsMaleMutationMyocytes, CardiacPatient SelectionAdrenergic AgonistsAnti-Arrhythmia AgentsCalsequestrinCASQ2 protein, humandrug therapyinduced pluripotent stem cellsmyocytes, cardiacstem celltachycardia, ventricular

Identifiers

PMID28630169
OpenAlexW2638423511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.