Evidence map›Paper›PMID 28630154›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017

Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport.

Nathan H Joh, Gevorg Grigoryan, Yibing Wu, William F DeGrado

Open access · bronzeAbstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Cell-Free Expression ofACS nano · 2023
    Article
  5. Light-Activated Assembly of Connexon Nanopores in Synthetic Cells.Journal of the American Chemical Society · 2023
    Article
  6. Review
  7. De novo metalloprotein design.Nature reviews. Chemistry · 2022
    Article
  8. Spiers Memorial Lecture: Analysis andFaraday discussions · 2021
    Article
  9. Article
  10. De novo design of transmembrane β barrels.Science (New York, N.Y.) · 2021
    Article
  11. Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Article
  13. Quarterly reviews of biophysics · 2020
    Review
  14. Article
  15. Review
  16. Membrane pores: from structure and assembly, to medicine and technology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nathan H JohDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA nate.joh@amgen.com.ORCID 0000-0003-3221-9325
Gevorg GrigoryanDepartment of Computer Science, Dartmouth College, Hanover, NH 03755, USA.
Yibing WuDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
William F DeGradoDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA william.degrado@ucsf.edu.
University of California, San Francisco · USDartmouth College · US

Funding

Deciphering the Mechanism of Transporters by Design and ExperimentsF32GM096727 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOH, NATHAN · 2011 to 2013
$128k
NIGMS NIH HHS F32 GM096727
6 · The paper itself

Abstract

Ion transporters and channels are able to identify and act on specific substrates among myriads of ions and molecules critical to cellular processes, such as homeostasis, cell signalling, nutrient influx and drug efflux. Recently, we designed Rocker, a minimalist model for Zn

Indexed as

Protein EngineeringCarrier ProteinsIon TransportMembrane ProteinsMolecular Dynamics SimulationProtein Structure, SecondaryCarrier ProteinsMembrane Proteinszinc-binding proteincomputational designmembrane protein foldingmetallotransporter

Identifiers

PMID28630154
PMCPMC5483517
OpenAlexW2670284967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.