ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Arabidopsis MACP2 contributes to autophagy induction by modulating starvation-induced reactive oxygen species homeostasis.Advanced biotechnology · 2025Article
- Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism.Nature communications · 2022Article
- Overexpression of theInternational journal of molecular sciences · 2022Article
- Increased Capsule Thickness and Hypermotility Are Traits of Carbapenem-ResistantOpen forum infectious diseases · 2021Article
- Review
- A novel allele of the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling.Genetics · 2021Article
- Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes.Frontiers in immunology · 2021Review
- Phylogenetic Analysis of the Membrane Attack Complex/Perforin Domain-Containing Proteins inFrontiers in plant science · 2021Article
- Frequent birth-and-death events throughout perforin-1 evolution.BMC evolutionary biology · 2020Article
- An Ancient Molecular Arms Race:Frontiers in immunology · 2020Review
- Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity.Science advances · 2020Article
- Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector.Frontiers in immunology · 2020Review
- Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Structures of monomeric and oligomeric forms of theScience advances · 2018Article
- Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress.Toxins · 2017Review
- Membrane pores: from structure and assembly, to medicine and technology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Pore-forming proteins play critical roles in pathogenic attack and immunological defence. The membrane attack complex/perforin (MACPF) group of homologues represents, with cholesterol-dependent cytolysins, the largest family of such proteins. In this review, we begin by describing briefly the structure of MACPF proteins, outlining their common mechanism of pore formation. We subsequently discuss some examples of MACPF proteins likely implicated in pore formation or other membrane-remodelling processes. Finally, we focus on astrotactin and bone morphogenetic protein and retinoic acid-induced neural-specific proteins, highly conserved MACPF family members involved in developmental processes, which have not been well studied to date or observed to form a pore-and which data suggest may act by alternative mechanisms.This article is part of the themed issue 'Membrane pores: from structure and assembly, to medicine and technology'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.