Evidence map›Paper›PMID 28630066›Full record

ArticleInfection and immunity2017

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2.

James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca K H Orth, Ashley Mansell, Eric C Reynolds

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Virulence · 2025
    Review
  2. Article
  3. Macrophage Cell Cycle.Results and problems in cell differentiation · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James A HoldenOral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
Neil M O'Brien-SimpsonOral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
Jason C LenzoOral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
Rebecca K H OrthOral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
Ashley MansellCentre for Innate Immunity and Infectious Disease, Monash Institute of Medical Research, Monash University, Clayton, Australia.
Eric C ReynoldsOral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia e.reynolds@unimelb.edu.au.
University of Melbourne · AUMonash Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Macrophage ActivationAnimalsCells, CulturedCytokinesInterferon-gammaMacrophagesMice, Inbred C57BLNitric OxideNod2 Signaling Adaptor ProteinPorphyromonasReceptors, Pattern RecognitionToll-Like Receptor 2Toll-Like Receptor 4CytokinesInterferon-gammaNitric OxideNod2 protein, mouseNod2 Signaling Adaptor ProteinReceptors, Pattern RecognitionTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4companion animalspattern recognition receptorsperiodontal diseasePorphyromonas gulae

Identifiers

PMID28630066
PMCPMC5563586
OpenAlexW2647520704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.