ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neuropsychological Diagnostic Tools in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Aging and disease · 2025Pooled it
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- A Systematic Review of Antidepressants and Psychotherapy Commonly Used in the Treatment of Late Life Depression for Their Effects on Cognition.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Pooled it
- My patient might be depressed - can I still screen for MCI? Exploring cognitive performance on the MoCA in older people screened for depressive symptoms with the PHQ-9.BMC geriatrics · 2025Trial
- Assessing the Relationship Between Volumetric Changes and Functional Connectivity in Patients with Mild Cognitive Impairment.Journal of clinical medicine · 2026Article
- Neuroprotective effects ofFrontiers in nutrition · 2026Article
- A new method for community-based intelligent screening of early Alzheimer's disease populations based on digital biomarkers of the writing process.Frontiers in computational neuroscience · 2025Article
- Disrupted topological organization of the default mode network in mild cognitive impairment with subsyndromal depression: A graph theoretical analysis.CNS neuroscience & therapeutics · 2024Article
- Mild behavioral impairment linked to progression to Alzheimer's disease and cortical thinning in amnestic mild cognitive impairment.Frontiers in aging neuroscience · 2022Article
- Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project.Biological psychiatry · 2021Article
- Depression and the Diagnosis of MCI in a Culturally Diverse Sample in the United States.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Depression in Alzheimer's Disease: A Delphi Consensus on Etiology, Risk Factors, and Clinical Management.Frontiers in psychiatry · 2021Article
- Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Luteolin Modulates Neural Stem Cells Fate Determination:Frontiers in cell and developmental biology · 2021Article
- Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study.Journal of Alzheimer's disease : JAD · 2021Article
- Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer's Coordinating Centers volunteers.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog): Modifications and Responsiveness in Pre-Dementia Populations. A Narrative Review.Journal of Alzheimer's disease : JAD · 2018Review
- Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms.Neural plasticity · 2018Article
- Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia.Dementia and geriatric cognitive disorders extraArticle
- Depression Severity, but Not Cognitive Impairment or Frailty, is Associated with Disability in Late-Life Depression.Clinical gerontologistArticle
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Abstract
objectivesTo investigate the association between cognitive decline and cortical atrophy in individuals with mild cognitive impairment (MCI) and chronic subsyndromal symptoms of depression (SSD) over a 4-year period.
designProspective cohort study.
settingMulticenter, clinic-based.
participantsWithin the Alzheimer's Disease Neuroimaging Initiative repository, the Neuropsychiatric Inventory was used to identify individuals with MCI and stable endorsement (SSD group N = 32) or no endorsement (non-SSD group N = 69) of depressive symptoms across time points. MEASUREMENTS: Repeated measures of cognitive outcomes, cortical atrophy, and their associations were evaluated with mixed effects models adjusting for age, education, sex, and APOE genotype.
resultsThe SSD group demonstrated accelerated decline on measures of global cognition (Alzheimer Disease Assessment Scale; df = 421, t = 2.242, p = 0.025), memory (Wechsler Memory Scale-Revised Logical Memory II; df = 244, t = -2.525, p = 0.011), information processing speed (Trail Making Test Parts A [df = 421, t = 2.376, p = 0.018] and B [df = 421, t = 2.533, p = 0.012]), and semantic fluency (Category Fluency; df = 424, t = -2.418, p = 0.016), as well as accelerated frontal lobe (df = 341, t = -2.648, p = 0.008) and anterior cingulate (df = 341, t = -3.786, p < 0.001) atrophy. No group differences were observed for rate of decline on measures of attention, learning, and confrontation naming or for rate of atrophy in any other regions. Accelerated frontal lobe and anterior cingulate atrophy was associated with cognitive decline on measures of global cognition, information processing speed, and semantic fluency (all p < 0.05), but not memory.
conclusionsIndividuals with chronic SSD may represent an MCI subgroup that is highly vulnerable to accelerated cognitive decline, an effect that may be governed by frontal lobe and anterior cingulate atrophy.
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