ArticleChest2017
Trajectories of Emergent Central Sleep Apnea During CPAP Therapy.
Article in Chest, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07530302 (Treatment Failure of Continuous Positive Airway Pressure), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment Failure of Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea Syndrome (OSA): A Randomized Controlled Trial Comparing Polysomnography and the Sunrise Device to Drive Treatment-Adjustment Decisions.
Who cites it
47 citing papers in PubMed, 119 citations in OpenAlex.
- Trial
- Therapeutic effects of oxygen inhalation for obstructive sleep apnea patients with high carotid body chemosensitivity.BMC pulmonary medicine · 2026Trial
- Prevalence and management of residual respiratory events in OSA patients treated with CPAP: a prospective observational clinical experience.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Concerns arising from the calculation of the apnea-hypopnea index during CPAP-telemonitoring of patients with obstructive sleep apnea.Respiratory research · 2025Article
- The combination of physiology and machine learning for prediction of CPAP pressure and residual AHI in OSA.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Treatment-emergent central sleep apnea resolves with lower inspiratory pressure.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Insights, recommendations, and research priorities for central sleep apnea: report from an expert panel.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Impact of Hypopnoea Classifications on the Assessment of Sleep Disordered Breathing in Heart Failure.Cardiac failure review · 2025Review
- Management of central sleep apnoea: a review of non-hypercapnic causes.Breathe (Sheffield, England) · 2024Review
- The prevalence and polysomnographic characteristics of treatment-emergent central sleep apnea with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Association Between Sleep Apnea Treatment and Health Care Resource Use in Patients With Atrial Fibrillation.Journal of the American Heart Association · 2024Article
- CPAP resumption after a first termination and impact on all-cause mortality in France.The European respiratory journal · 2024Article
- Central sleep apnoea: not just one phenotype.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Reversible central respiratory events induced by valproic acid treatment: A case report.SAGE open medical case reports · 2024Article
- Article
- The prevalence of treatment-emergent central sleep apnea with mandibular advancement device therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Dose-Response Relationship between Obstructive Sleep Apnea Therapy Adherence and Healthcare Utilization.Annals of the American Thoracic Society · 2023Article
- Review
- Central Sleep Apnea in Adults: Diagnosis and Treatment.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023Article
- Association between positive airway pressure therapy adherence and health care resource utilization in patients with obstructive sleep apnea and type 2 diabetes in the United States.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe emergence of central sleep apnea (CSA) during positive airway pressure (PAP) therapy has been observed clinically in approximately 10% of obstructive sleep apnea titration studies. This study assessed a PAP database to investigate trajectories of treatment-emergent CSA during continuous PAP (CPAP) therapy.
methodsU.S. telemonitoring device data were analyzed for the presence/absence of emergent CSA at baseline (week 1) and week 13. Defined groups were as follows: obstructive sleep apnea (average central apnea index [CAI] < 5/h in week 1, < 5/h in week 13); transient CSA (CAI ≥ 5/h in week 1, < 5/h in week 13); persistent CSA (CAI ≥ 5/h in week 1, ≥ 5/h in week 13); emergent CSA (CAI < 5/h in week 1, ≥ 5/h in week 13).
resultsPatients (133,006) used CPAP for ≥ 90 days and had ≥ 1 day with use of ≥ 1 h in week 1 and week 13. The proportion of patients with CSA in week 1 or week 13 was 3.5%; of these, CSA was transient, persistent, or emergent in 55.1%, 25.2%, and 19.7%, respectively. Patients with vs without treatment-emergent CSA were older, had higher residual apnea-hypopnea index and CAI at week 13, and more leaks (all P < .001). Patients with any treatment-emergent CSA were at higher risk of therapy termination vs those who did not develop CSA (all P < .001).
conclusionsOur study identified a variety of CSA trajectories during CPAP therapy, identifying several different clinical phenotypes. Identification of treatment-emergent CSA by telemonitoring could facilitate early intervention to reduce the risk of therapy discontinuation and shift to more efficient ventilator modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.