Evidence map›Paper›PMID 28629744›Full record

ArticleThe Journal of allergy and clinical immunology2018

Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.

Yufeng Zhou, Danh C Do, Faoud T Ishmael, Mario Leonardo Squadrito, Ho Man Tang, Ho Lam Tang, Man-Hsun Hsu, Lipeng Qiu, Changjun Li, Yongqing Zhang and 4 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026
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  13. Biochanin A exerts an anti-inflammatory effect on adipose tissue and liver of ovariectomized obese mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  14. Review
  15. Macrophages and Pulmonary Fibrosis.Current molecular medicine · 2025
    Review
  16. Review
  17. Article
  18. Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Yufeng ZhouJohns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Md; Children's Hospital and the Institute of Biomedical Sciences and, Fudan University, and Key Laboratory of Neonatal Diseases, Ministry of Health, Shanghai, China.
Danh C DoJohns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Md.
Faoud T IshmaelDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pa.
Mario Leonardo SquadritoSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Ho Man TangInstitute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Md.
Ho Lam TangDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md.
Man-Hsun HsuDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, Pa.
Lipeng QiuJohns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Md.
Changjun LiDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Yongqing ZhangGene Expression & Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, Md.
Kevin G BeckerGene Expression & Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, Md.
Mei WanDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Shau-Ku HuangJohns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Md; National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Lou-Hu Hospital, Shen-Zhen University, Shen-Zhen, China. Electronic address: skhuang@nhri.org.tw.
Peisong GaoJohns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address: pgao1@jhmi.edu.
Johns Hopkins Medicine · USNational Institutes of Health · USÉcole Polytechnique Fédérale de Lausanne · CHKaohsiung Medical University · TWPenn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Analysis of complex biological systems by microarray based gene expressionZICAG000616 · NIA · NATIONAL INSTITUTE ON AGING · PI DE, SUPRIYO · 2009 to 2025
$15.5M
Sensitization to Cockroach Allergen: Immune Regulation and Genetic DeterminantsR01ES021739 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2013 to 2017
$1.8M
Mannose Receptor, miR-511-3p, and Macrophage Polarization in AsthmaR21AI121768 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2016 to 2017
$462k
Lineage Commitment of Mesenchymal Stem Cell in Allergen-induced Airway RemodelingR21AI109062 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2014 to 2015
$446k
HSRD VA CDA 10-014Intramural NIH HHS Z99 AG999999NIAID NIH HHS R21 AI109062NIAID NIH HHS R21 AI121768NIEHS NIH HHS R01 ES021739
6 · The paper itself

Abstract

backgroundMannose receptor (MRC1/CD206) has been suggested to mediate allergic sensitization and asthma to multiple glycoallergens, including cockroach allergens.

objectiveWe sought to determine the existence of a protective mechanism through which MRC1 limits allergic inflammation through its intronic miR-511-3p.

methodsWe examined MRC1-mediated cockroach allergen uptake by lung macrophages and lung inflammation using C57BL/6 wild-type (WT) and Mrc1

resultsMrc1

conclusionThese studies support a critical but previously unrecognized role of MRC1 and miR-511-3p in protection against allergen-induced lung inflammation.

Indexed as

AllergensAnimalsAsthmaCockroachesGene Expression ProfilingGene Expression RegulationGenetic VectorsHypersensitivityLectins, C-TypeMacrophage ActivationMacrophagesMacrophages, AlveolarMannose-Binding LectinsMannose ReceptorMembrane GlycoproteinsMiceAllergensLectins, C-TypeMannose-Binding LectinsMannose ReceptorMembrane GlycoproteinsMicroRNAsMirn511 microRNA, mouseMRC1 protein, mouseReceptors, Cell SurfaceReceptors, ImmunologicasthmamacrophageMannose receptormiR-511-3p

Identifiers

PMID28629744
PMCPMC5944850
OpenAlexW2598533679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.