Evidence map›Paper›PMID 28629576›Full record

ArticleEuropean journal of radiology2017

Differentiation of brain tumor-related edema based on 3D T1rho imaging.

J E Villanueva-Meyer, R F Barajas, M C Mabray, W Chen, A Shankaranarayanan, P Koon, I J Barani, T Tihan, S Cha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. TNMR in biomedicine · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. TNMR in biomedicine · 2020
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

J E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: javier.villanueva-meyer@ucsf.edu.
R F BarajasDepartment of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA; Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA. Electronic address: barajas@ohsu.edu.
M C MabrayDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: mamabray@salud.unm.edu.
W ChenDepartment Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China. Electronic address: wtchen@cuhk.edu.hk.
A ShankaranarayananGlobal Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA. Electronic address: ajit.shankaranarayanan@med.ge.com.
P KoonGlobal Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA. Electronic address: patrick.koon@med.ge.com.
I J BaraniDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA. Electronic address: ibarani@gmail.com.
T TihanDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
S ChaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. Electronic address: soonmee.cha@ucsf.edu.
University of California, San Francisco · USApplied Sciences Laboratory (United States) · USUniversity of California System · USAdvanced Imaging Research (United States) · USChinese University of Hong Kong · CN

Funding

Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

background and purposeCerebral edema associated with brain tumors is an important source of morbidity. Its type depends largely on the capillary ultra-structures of the histopathologic subtype of underlying brain tumor. The purpose of our study was to differentiate vasogenic edema associated with brain metastases and infiltrative edema related to diffuse gliomas using quantitative 3D T1 rho (T1ρ) imaging. MATERIALS AND

methodsPreoperative MR examination including whole brain 3D T1ρ imaging was performed in 23 patients with newly diagnosed brain tumors (9 with metastasis, 8 with lower grade glioma, LGG, 6 with glioblastoma, GBM). Mean T1ρ values were measured in regions of peritumoral non-enhancing T2 signal hyperintensity, excluding both enhancing and necrotic or cystic component, and normal-appearing white matter.

resultsMean T1ρ values were significantly elevated in the vasogenic edema surrounding intracranial metastases when compared to the infiltrative edema associated with either LGG or GBM (p=0.02 and <0.01, respectively). No significant difference was noted between T1ρ values of infiltrative edema between LGG and GBM (p=0.84 and 0.96, respectively).

conclusionOur study demonstrates the feasibility and potential diagnostic role of T1ρ in the quantitative differentiation between edema related to intracranial metastases and gliomas and as a potentially complementary tool to standard MR techniques in further characterizing pathophysiology of vasogenic and infiltrative edema.

Indexed as

Brain EdemaBrain NeoplasmsDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingGlioblastomaGliomaHumansMagnetic Resonance ImagingGliomaInfiltrative edemaMetastasisPeritumoral edemaT1rhoVasogenic edema

Identifiers

PMID28629576
PMCPMC5563444
OpenAlexW2600136254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.