Three-dimensional substructure measurements for the differential diagnosis of ground glass nodules.

Mingzheng Peng, Gang Yu, Chengzhong Zhang, Cuidi Li, Jinwu Wang

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Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Mingzheng PengShanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School Of Medicine, Room 703, No. 3 Building, 693 Zhizaoju Road, Shanghai, 200011, China.

Gang YuDepartment of Anesthesiology, Binzhou Central Hospital, Binzhou Medical College, Binzhou, China.

Chengzhong ZhangDepartment of Radiology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cuidi LiSchool of Biomedical Engineering, MED-X Research Institute of Shanghai Jiao Tong University, Shanghai, China.

Jinwu WangShanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School Of Medicine, Room 703, No. 3 Building, 693 Zhizaoju Road, Shanghai, 200011, China. 156816117@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe analyzed the differences between maximum and peak computed tomography (CT) numbers (M-P), respectively representing the densities of the solid center and the main periphery of ground-glass nodules (GGNs), and the average change in M-P velocity (V(M-P)) during follow-up to differentiate between pre-invasive (PIA) and invasive adenocarcinoma (IAC).

methodsData of 102 patients were retrospectively collected and analyzed in our study including 43 PIAs and 59 IACs. Diameters, total volumes, and the maximum and peak CT numbers in CT number histograms were measured and followed for at least 3 months. This study was registered retrospectively.

resultsThe M-P values for IACs were higher than those for PIAs (p = 0.001), with an area under the curve (AUC) of 0.810 and a threshold of 489.5 Hounsfield units (HU) in ROC analysis. The V(M-P) values for IACs were smaller than those for PIAs (p = 0.04), with an AUC of 0.805 and a threshold of 11.01 HU/day.

conclusionsM-P and V(M-P) values may help distinguish IACs from PIAs by representing the changes in the sub-structural densities of GGNs during follow-up.

Indexed as

AdenocarcinomaAgedArea Under CurveDiagnosis, DifferentialFemaleHumansImaging, Three-DimensionalLung NeoplasmsMaleMiddle AgedMultiple Pulmonary NodulesNeoplasm InvasivenessRetrospective StudiesROC CurveSolitary Pulmonary NoduleTomography, X-Ray ComputedFollow-upGround-glass noduleLung cancerPeakSubstructureThree-dimensional

Identifiers

PMID28629453

DOI10.1186/s12890-017-0438-y

PMCPMC5477248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.