ArticleBMC surgery2017
The utility of the hematoxylin and eosin staining in patients with suspected Hirschsprung disease.
Article in BMC surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Key H&E morphologic features associated with preoperative misdiagnosis of presacral neoplasms: a retrospective slide re-review study.Frontiers in oncology · 2026Article
- BMP-2 promotes fracture healing by facilitating osteoblast differentiation and bone defect osteogenesis.American journal of translational research · 2023Article
- A new systematization of histological analysis for the diagnosis of Hirschsprung's disease.Clinics (Sao Paulo, Brazil) · 2023Article
- A comparison of hepatotoxicity induced by different lengths of tungsten trioxide nanorods and the protective effects of melatonin in BALB/c mice.Environmental science and pollution research international · 2021Article
- Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease.The Journal of international medical research · 2021Article
- Long-term growth outcomes in children with Hirschsprung disease after definitive surgery: A cross-sectional study.Annals of medicine and surgery (2012) · 2020Article
- Comparison of pre-operative Hirschsprung-associated enterocolitis using classical criteria and Delphi method: A diagnostic study.Annals of medicine and surgery (2012) · 2020Article
- Accuracy of transition zone in contrast enema to predict intraoperative aganglionosis level in patients with Hirschsprung disease.BMC research notes · 2020Article
- Aberrant expressions of miRNA-206 target, FN1, in multifactorial Hirschsprung disease.Orphanet journal of rare diseases · 2019Article
- Risk factors of preoperative Hirschsprung-associated enterocolitis.BMC proceedings · 2019Article
- NRG1 variant effects in patients with Hirschsprung disease.BMC pediatrics · 2018Article
- Atypical onset of total colonic Hirschsprung disease in a small female infant: A case report.Medicine · 2018Article
- Liver transplant score for prediction of biliary atresia patients' survival following Kasai procedure.BMC research notes · 2018Article
- The impact of down-regulated SK3 expressions on Hirschsprung disease.BMC medical genetics · 2018Article
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Abstract
backgroundWhile immunohistochemistry (IHC) methods have been widely conducted for the diagnosis of Hirschsprung disease (HSCR) in developed countries, there are very few studies on their use in developing countries where hematoxylin and eosin (HE) staining is a key element of the diagnosis of HSCR. We aimed to determine the accuracy of HE staining in the diagnosis of HSCR using S100 IHC as the reference standard in Indonesia.
methodsAll histopathology performed for the suspicion of HSCR patients from January 2013 to August 2015 in Dr. Sardjito Hospital, Yogyakarta, Indonesia, were retrospectively reviewed.
resultsOur study included 23 HSCR patients: 9 males and 14 females. The HE staining revealed 14 negative (absence of ganglion cells) cases (61%) and 9 positive (presence of ganglion cells) cases (39%). In S100 IHC, out of the 9 positive cases by HE staining, 6 (67%) were confirmed for having ganglion cells; and out of the 14 negative cases by HE staining, 12 (86%) were reported negative and 2 (14%) were positive by S100 IHC staining. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rates of the HE staining were 80% (95% CI: 0.51-0.95), 75% (95% CI: 0.36-0.96), 85.7% (95% CI: 0.56-0.98), 66.7% (95% CI: 0.31-0.91), and 78.3% (95% CI: 0.58-0.90), respectively.
conclusionsOur study showed that HE staining has relatively moderate accuracy for the diagnosis of HSCR. The use of HE staining is still recommended for the diagnosis of HSCR given the limitation of resource allocation for more expensive IHC technologies in developing countries.
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