ArticlePharmaceutical biology2017
Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
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- Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice.Frontiers in pharmacology · 2025Article
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- Application of Response Surface Methodology (RSM) for the Optimization of Ultrasound-Assisted Extraction (UAE) ofPlants (Basel, Switzerland) · 2023Article
- A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Molecules (Basel, Switzerland) · 2022Article
- Revealing the Acetylcholinesterase Inhibitory Potential ofBioinformatics and biology insights · 2022Article
- In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer's Disease.Current issues in molecular biology · 2021Article
- UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction ofPharmaceutical biology · 2021Article
- Effect of habitat variations on the chemical composition, antioxidant, and antimicrobial activities ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer's Disease.Brain sciences · 2021Article
- Article
- Biochemical Profiling and Elucidation of Biological Activities ofSaudi journal of biological sciences · 2021Article
- Potential Nutraceutical Properties of Leaves from Several Commonly Cultivated Plants.Biomolecules · 2020Article
- The botanical origin and antioxidant, anti-BACE1 and antiproliferative properties of bee pollen from different regions of South Korea.BMC complementary medicine and therapies · 2020Article
- An Investigation of Potential Sources of Nutraceuticals from the Niger Delta Areas, Nigeria for Attenuating Oxidative Stress.Medicines (Basel, Switzerland) · 2019Article
- Article
- In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts ofMedicines (Basel, Switzerland) · 2018Article
- Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor.Chemistry Central journal · 2018Article
- In vitro Anti-cholinesterase and Anti-oxidant Activity of Three Standardised Polyherbal Products Used for Memory Enhancing in Ethnomedicine of South-East Nigeria.The Malaysian journal of medical sciences : MJMS · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThere is an unmet need to discover new treatments for Alzheimer's disease. This study determined the anti-acetylcholinesterase (AChE) activity, DPPH free radical scavenging and antioxidant properties of Carpolobia lutea G. Don (Polygalaceae).
objectiveThe objective of this study is to quantify C. lutea anti-AChE, DPPH free radical scavenging, and antioxidant activities and cell cytotoxicity. MATERIALS AND
methodsPlant stem, leaves and roots were subjected to sequential solvent extractions, and screened for anti-AChE activity across a concentration range of 0.02-200 μg/mL. Plant DPPH radical scavenging activity, reducing power, and total phenolic and flavonoid contents were determined, and cytotoxicity evaluated using human hepatocytes.
resultsCarpolobia lutea exhibited concentration-dependent anti-AChE activity. The most potent inhibitory activity for the stem was the crude ethanol extract and hexane stem fraction oil (IC DISCUSSION AND
conclusionsCarpolobia lutea possesses anti-AChE activity and beneficial antioxidant capacity indicative of its potential development as a treatment of Alzheimer's and other diseases characterized by a cholinergic deficit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.