ArticleHealth psychology review2017
Dynamic modelling of n-of-1 data: powerful and flexible data analytics applied to individualised studies.
Article in Health psychology review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Are digital health interventions valuable to support patients with cancer and caregivers? An umbrella review of web-based and app-based supportive care interventions.Cancer medicine · 2023Pooled it
- A systematic review of ecological momentary assessment studies of appetite and affect in the experience of temptations and lapses during weight loss dieting.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- A series of N-of-1 dietary intervention studies with whole-grain foods and nuts reveals individual predictors of blood pressure and heart rate.European journal of clinical nutrition · 2026Trial
- Double-blind randomized N-of-1 trial of transcranial alternating current stimulation for mal de débarquement syndrome.PloS one · 2022Trial
- Digital N-of-1 trials and their application in experimental physiology.Experimental physiology · 2026Review
- Personal Health and Well-Being Determinants Associated with the Day-to-Day Variability of Sedentary Behaviour in Community-Dwelling People with Stroke.Journal of clinical medicine · 2025Article
- Article
- Efficacy and Safety of Photobiomodulation in MELAS: Protocol for a Series of N-of-1 Trials.Journal of clinical medicine · 2025Article
- Linking physical activity to workers' low back pain, back health, and theory-based psychological variables: study protocol of the workHealth intensive longitudinal observational study.BMC public health · 2025Article
- Testing unit root non-stationarity in the presence of missing data in univariate time series of mobile health studies.Journal of the Royal Statistical Society. Series C, Applied statistics · 2024Article
- Multivariate variable selection in N-of-1 observational studies via additive Bayesian networks.PloS one · 2024Article
- Biofeedback and Digitalized Motivational Interviewing to Increase Daily Physical Activity: Series of Factorial N-of-1 Randomized Controlled Trials Piloting the Precious App.JMIR formative research · 2023Article
- An ideographic study into physiology, alcohol craving and lapses during one hundred days of daily life monitoring.Addictive behaviors reports · 2022Article
- A Useful and Sustainable Role for N-of-1 Trials in the Healthcare Ecosystem.Clinical pharmacology and therapeutics · 2022Review
- Article
- Day-to-day associations between sleep and physical activity: a set of person-specific analyses in adults with overweight and obesity.Journal of behavioral medicine · 2022Article
- Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent-Umbrella-Bucket Design.Journal of personalized medicine · 2022Article
- A protocol for longitudinal monitoring of individual building occupants and their environments.PloS one · 2022Article
- COVID-19 related interdisciplinary methods: Preventing errors and detecting research opportunities.Methods (San Diego, Calif.) · 2021Review
- Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs.Contemporary clinical trials communications · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
N-of-1 studies are based on repeated observations within an individual or unit over time and are acknowledged as an important research method for generating scientific evidence about the health or behaviour of an individual. Statistical analyses of n-of-1 data require accurate modelling of the outcome while accounting for its distribution, time-related trend and error structures (e.g., autocorrelation) as well as reporting readily usable contextualised effect sizes for decision-making. A number of statistical approaches have been documented but no consensus exists on which method is most appropriate for which type of n-of-1 design. We discuss the statistical considerations for analysing n-of-1 studies and briefly review some currently used methodologies. We describe dynamic regression modelling as a flexible and powerful approach, adaptable to different types of outcomes and capable of dealing with the different challenges inherent to n-of-1 statistical modelling. Dynamic modelling borrows ideas from longitudinal and event history methodologies which explicitly incorporate the role of time and the influence of past on future. We also present an illustrative example of the use of dynamic regression on monitoring physical activity during the retirement transition. Dynamic modelling has the potential to expand researchers' access to robust and user-friendly statistical methods for individualised studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.