Evidence map›Paper›PMID 28629225›Full record

ReviewASN neuro

Cortical Plasticity in Depression.

Mariagiovanna Cantone, Alessia Bramanti, Giuseppe Lanza, Manuela Pennisi, Placido Bramanti, Giovanni Pennisi, Rita Bella

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ASN neuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06735794 (Spaced iTBS), which is not on this map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06735794 nacompletednot on this map

Spaced iTBS: Effects on Plasticity in the Motor Cortex

TypeinterventionalSponsorCentre for Addiction and Mental HealthRan2024 to 2026Enrolled29ConditionsHealthy Control SubjectsArmsCompressed iTBS, Spaced iTBS, Sham iTBS
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  9. Sensory Entrained TMS (seTMS) enhances motor cortex plasticity.bioRxiv : the preprint server for biology · 2025
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  12. Review
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mariagiovanna Cantone1 Department of Neurology IC, IRCCS " Oasi" Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
Alessia Bramanti2 IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
Giuseppe Lanza1 Department of Neurology IC, IRCCS " Oasi" Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
Manuela Pennisi3 Spinal Unit, Emergency Hospital Cannizzaro, Catania, Italy.
Placido Bramanti2 IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
Giovanni Pennisi4 Department of Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
Rita Bella5 Department of Medical and Surgical Sciences and Advanced Technology, Section of Neurosciences, University of Catania, Catania, Italy.
Centro Neurolesi Bonino Pulejo · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Catania · ITOspedale Cannizzaro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression. Moreover, a degree of cognitive impairment is frequently observed throughout the clinical spectrum of mood disorders, and the relationship between depression and cognition is often bidirectional. However, most evidence for dysfunctional neural plasticity in depression has been indirect. Transcranial magnetic stimulation has emerged as a noninvasive tool for investigating several parameters of cortical excitability with the aim of exploring the functions of different neurotransmission pathways and for probing in vivo plasticity in both healthy humans and those with pathological conditions. In particular, depressed patients exhibit a significant interhemispheric difference in motor cortex excitability, an imbalanced inhibitory or excitatory intracortical neurochemical circuitry, reduced postexercise facilitation, and an impaired long-term potentiation-like response to paired-associative transcranial magnetic stimulation, and these symptoms may indicate disrupted plasticity. Research aimed at disentangling the mechanism by which neuroplasticity plays a role in the pathological processes that lead to depression and evaluating the effects of modulating neuroplasticity are needed for the field to facilitate more powerful translational research studies and identify novel therapeutic targets.

Indexed as

Neuronal PlasticityTranscranial Magnetic StimulationAnimalsBrainHumansMajor Depressive Disordercortical excitabilitymajor depressionmood disordersnon-invasive brain stimulationsynaptic plasticity

Identifiers

PMID28629225
PMCPMC5480639
OpenAlexW2673454223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.