Evidence map›Paper›PMID 28629188›Full record

ArticleInternational journal of molecular sciences2017

Serum Biomarkers for Discrimination between Hepatitis C-Related Arthropathy and Early Rheumatoid Arthritis.

Isabela Siloşi, Lidia Boldeanu, Viorel Biciuşcă, Maria Bogdan, Carmen Avramescu, Citto Taisescu, Vlad Padureanu, Mihail Virgil Boldeanu, Anica Dricu, Cristian Adrian Siloşi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. JAK/STAT pathway in pathology of rheumatoid arthritis (Review).Experimental and therapeutic medicine · 2020
    Review
  8. Review
  9. Review
  10. Host immune response in chronic hepatitis C infection: involvement of cytokines and inflammasomes.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Isabela SiloşiDepartment of Immunology-Laboratory of Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200349, Romania. isabela_silosi@yahoo.com.
Lidia BoldeanuDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200690, Romania. barulidia@yahoo.com.
Viorel BiciuşcăDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200690, Romania. biciuscaviorel@gmail.com.
Maria BogdanDepartment of Pharmacology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200349, Romania. bogdanfmaria81@yahoo.com.
Carmen AvramescuDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200690, Romania. c.avramescu@yahoo.com.
Citto TaisescuDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200690, Romania. taisescu@yahoo.com.
Vlad PadureanuDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200690, Romania. vldpadureanu@yahoo.com.
Mihail Virgil BoldeanuDepartment of Immunology-Laboratory of Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200349, Romania. mihail.boldeanu@umfcv.ro.
Anica DricuDepartment of Functional Sciences, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200690, Romania. anica.dricu@live.co.uk.
Cristian Adrian SiloşiDepartment of Surgery, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, Craiova 200349, Romania. cristian_silosi@yahoo.fr.
University of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we aimed to estimate the concentrations of cytokines (interleukin 6, IL-6, tumor necrosis factor-α, TNF-α) and auto-antibodies (rheumatoid factor IgM isotype, IgM-RF, antinuclear auto-antibodies, ANA, anti-cyclic citrullinated peptide antibodies IgG isotype, IgG anti-CCP3.1, anti-cardiolipin IgG isotype, IgG anti-aCL) in serum of patients with eRA (early rheumatoid arthritis) and HCVrA (hepatitis C virus-related arthropathy) and to assess the utility of IL-6, TNF-α together with IgG anti-CCP and IgM-RF in distinguishing between patients with true eRA and HCVrA, in the idea of using them as differential immunomarkers. Serum samples were collected from 54 patients (30 diagnosed with eRA-subgroup 1 and 24 with HCVrA-subgroup 2) and from 28 healthy control persons. For the evaluation of serum concentrations of studied cytokines and auto-antibodies, we used immunoenzimatique techniques. The serum concentrations of both proinflammatory cytokines were statistically significantly higher in patients of subgroup 1 and subgroup 2, compared to the control group (

Indexed as

AdultAgedArthritis, RheumatoidAutoantibodiesBiomarkersCardiolipinsCohort StudiesCryoglobulinemiaCytokinesFemaleHepacivirusHepatitis CHumansImmunoglobulin GInterleukin-6Joint DiseasesAutoantibodiesBiomarkersCardiolipinsCytokinesIL6 protein, humanImmunoglobulin GInterleukin-6Rheumatoid FactorTumor Necrosis Factor-alphaearly rheumatoid arthritishepatitis C virus-related arthritisinterleukin 6tumor necrosis factor-α

Identifiers

PMID28629188
PMCPMC5486125
OpenAlexW2625507690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.