ReviewInternational journal of molecular sciences2017
The Role of HCG in Implantation: A Mini-Review of Molecular and Clinical Evidence.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05340010 (Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Administration of Human Chorionic Gonadotrophin Before Secretory Transformation of Frozen-thawed Embryo Transfer Cycles
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Meta-analysis of intrauterine hCG perfusion efficacy in recurrent implantation failure as defined by ESHRE guidelines.BMC pregnancy and childbirth · 2024Pooled it
- Intrauterine administration of peripheral mononuclear cells in recurrent implantation failure: a systematic review and meta-analysis.Scientific reports · 2019Pooled it
- Investigating the Optimal Time for Intrauterine Human Chorionic Gonadotropin Infusion in Order to Improve IVF Outcome: A Systematic Review and Meta-Analysis.In vivo (Athens, Greece)Pooled it
- Intramuscular injection of human chorionic gonadotropin as luteal phase support in artificial cycle frozen-thawed embryo transfer does not improve clinical outcomes: a parallel, open-label randomized trial.Frontiers in endocrinology · 2023Trial
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- The Effect of Intramuscular Human Chorionic Gonadotropin on Endometrial Preparation in Frozen-Thawed Embryo Transfer: A Randomized Clinical Trial.International journal of fertility & sterility · 2026Article
- Localization of Luteinizing Hormone (LH) Subunits Like Substances in the Mouse Placenta.Development & reproduction · 2026Review
- Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF.International journal of molecular sciences · 2025Review
- Serum human chorionic gonadotropin can predict live birth 7 days after frozen-thawed blastocyst transfer.F&S reports · 2025Article
- Review
- Human Chorionic Gonadotropin as a Marker of Parathyroid Carcinoma: Findings From a Scoping Review.Cureus · 2025Review
- Evaluating endometrial response to human chorionic gonadotropin: alterations in epigenetic regulation and extracellular vesicle cargo of endometrial stromal cells.Human reproduction open · 2025Article
- Acupuncture as an adjunct therapy for enhancing endometrial receptivity in female infertility: a literature review.Frontiers in physiology · 2025Review
- Events Leading to the Establishment of Pregnancy and Placental Formation: The Need to Fine-Tune the Nomenclature on Pregnancy and Gestation.International journal of molecular sciences · 2023Review
- Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor.International journal of molecular sciences · 2023Article
- Effect of intramuscular injection of human chorionic gonadotropin on endometrium preparation in frozen-thawed embryo transfer cycle: A randomized clinical trial.Caspian journal of internal medicine · 2023Article
- Two subtypes of surgery-categorized upper-lateral intracavitary pregnancy identified by MRI, a retrospective study.BMC pregnancy and childbirth · 2022Article
- Article
- The effect of intrauterine hCG injection before embryo transfer on pregnancy rate in frozen embryo transfer cycles.Annals of medicine and surgery (2012) · 2022Article
- Intrauterine Instillation of Human Chorionic Gonadotropin with Intrauterine Insemination Catheter Around the Golden Time of Embryo Transfer Does Not ImproveReports of biochemistry & molecular biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryo implantation is a complex process involving continuous molecular cross-talk between the embryo and the decidua. One of the key molecules during this process is human chorionic gonadotropin (HCG). HCG effectively modulates several metabolic pathways within the decidua contributing to endometrial receptivity. Herein, a brief overview of the molecular mechanisms regulated by HCG is presented. Furthermore, we summarize the existing evidence regarding the clinical impact on reproductive outcomes after endometrial priming with HCG prior to embryo transfer. Although promising, further evidence is needed to clarify the protocol that would lead to beneficial outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.