ReviewInternational journal of molecular sciences2017
Age-Related Changes in Immunological and Physiological Responses Following Pulmonary Challenge.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Clinical Characteristics and Diagnostic Challenges of COVID-19: An Update From the Global Perspective.Frontiers in public health · 2020Pooled it
- Disparities in COVID-19 mortality in the United States, 2020-2023.BMC public health · 2025Article
- Age influences blood cell-based immune deregulation antibody response and unfavorable clinical outcomes in COVID-19 patients.Scientific reports · 2025Article
- A vasculature-resident innate lymphoid cell population in mouse lungs.Nature communications · 2025Article
- Dexmedetomidine administration is associated with reduced mortality in patients with sepsis-induced acute respiratory distress syndrome: a retrospective study.BMC anesthesiology · 2025Article
- Modeling COVID-19 transmission between age groups in the United States considering virus mutations, vaccinations, and reinfection.Scientific reports · 2022Article
- Comparative clinical characteristics among different age group of adult COVID-19 patients: A multicenter study.Immunity, inflammation and disease · 2022Article
- Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19.Inflammopharmacology · 2022Article
- How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways.Physics of fluids (Woodbury, N.Y. : 1994) · 2021Article
- Cytokine Storm and Failed Resolution in COVID-19: Taking a Cue from Multiple Sclerosis.Advances in experimental medicine and biology · 2021Article
- Association between age and clinical characteristics and outcomes of COVID-19.The European respiratory journal · 2020Article
- The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.Frontiers in medicine · 2020Review
- Geriatric Population During the COVID-19 Pandemic: Problems, Considerations, Exigencies, and Beyond.Frontiers in public health · 2020Review
- Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19.Frontiers in immunology · 2020Review
- Patterns of Deterioration in Moderate Patients With COVID-19 From Jan 2020 to Mar 2020: A Multi-Center, Retrospective Cohort Study in China.Frontiers in medicine · 2020Article
- Alda-1 attenuates hyperoxia-induced mitochondrial dysfunction in lung vascular endothelial cells.Aging · 2019Article
- Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study.Revista Brasileira de terapia intensiva · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
This review examines the current status of knowledge of sepsis and pneumonia in the elderly population and how the dynamics of the pulmonary challenge affects outcome and consequences. Led by an unprecedented shift in demographics, where a larger proportion of the population will reach an older age, clinical and experimental research shows that aging is associated with certain pulmonary changes, but it is during infectious insult of the lungs, as in the case of pneumonia, that the age-related differences in responsiveness and endurance become obvious and lead to a worse outcome than in the younger population. This review points to the neutrophil, and the endothelium as important players in understanding age-associated changes in responsiveness to infectious challenge of the lung. It also addresses how the immunological set-point influences injury-repair phases, remote organ damage and how intake of drugs may alter the state of responsiveness in the users. Further, it points out the importance of considering age as a factor in inclusion criteria in clinical trials, in vitro/ex vivo experimental designs and overall interpretation of results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.