Evidence map›Paper›PMID 28629119›Full record

ArticleMolecules (Basel, Switzerland)2017

Cholinesterase Inhibitory Activities of Adamantyl-Based Derivatives and Their Molecular Docking Studies.

Huey Chong Kwong, Siau Hui Mah, Tze Shyang Chia, Ching Kheng Quah, Gin Keat Lim, C S Chidan Kumar

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Huey Chong KwongSchool of Chemical Sciences, Universiti Sains Malaysia, Penang 11800 USM, Malaysia. stonekg01@gmail.com.
Siau Hui MahSchool of Biosciences, Taylor's University, Lakeside Campus, 47500 Subang Jaya, Selangor, Malaysia. SiauHui.Mah@taylors.edu.my.
Tze Shyang ChiaX-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia. chiatzeshyang@hotmail.com.
Ching Kheng QuahX-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang 11800 USM, Malaysia. ckquah@usm.my.
Gin Keat LimSchool of Chemical Sciences, Universiti Sains Malaysia, Penang 11800 USM, Malaysia. limgk@usm.my.
C S Chidan KumarDepartment of Engineering Chemistry, Vidya Vikas Institute of Engineering & Technology, Visvesvaraya Technological University, Alanahalli, Mysuru 570028, Karnataka, India. chidankumar@gmail.com.
Universiti Sains Malaysia · MYTaylor's University · MYVisvesvaraya Technological University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adamantyl-based compounds are clinically important for the treatments of type 2 diabetes and for their antiviral abilities, while many more are under development for other pharmaceutical uses. This study focused on the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of adamantyl-based ester derivatives with various substituents on the phenyl ring using Ellman's colorimetric method. Compound

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationAcetylcholinesteraseBinding SitesCatalytic DomainCholinesterase InhibitorsDose-Response Relationship, DrugInhibitory Concentration 50Molecular ConformationProtein BindingStructure-Activity RelationshipAcetylcholinesteraseCholinesterase Inhibitorsacetylcholinesteraseadamantanebutyrylcholinesterasemolecular docking

Identifiers

PMID28629119
PMCPMC6152672
OpenAlexW2626378823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.