ArticleJournal of affective disorders2017
Multi-modal neuroimaging of adolescents with non-suicidal self-injury: Amygdala functional connectivity.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 117 citations in OpenAlex.
- Intermittent theta burst stimulation for non-suicidal self-injury in adolescents with major depressive disorder: a randomized, sham-controlled trial.Molecular psychiatry · 2026Trial
- Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: A randomized, sham-controlled trial.NeuroImage. Clinical · 2022Trial
- Neural correlates of clinical improvement in response to N-acetylcysteine in adolescents with non-suicidal self-injury.Progress in neuro-psychopharmacology & biological psychiatry · 2020Trial
- Anxiety influences the addictive feature of non-suicidal self-injury behavior via somatic symptom in adolescents with major depressive disorder.Molecular psychiatry · 2026Article
- Analysis of brain volumetry and functional connectivity during resting state in patients with borderline personality disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Relief and blunted defensive conditioned responses in girls with non-suicidal self-injury behaviors.European child & adolescent psychiatry · 2026Article
- Emotion regulation mediates the effect of insomnia on non-suicidal self-injury in adolescents: the moderating role of mindfulness.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Abnormal Dynamic Functional Connectivity Within the Fronto-Limbic Network Mediates the Association Between Depressive Symptoms and Non-Suicidal Self-Injury in Adolescents.CNS neuroscience & therapeutics · 2026Article
- Longitudinal changes in amygdala-supplementary motor area connectivity and their association with recurrent self-harm in adolescents with mood disorders.BMC psychiatry · 2026Article
- Impulsivity in adolescents with MDD and non-suicidal self-injury: a multimodal assessment using psychometric, behavioral, and neurophysiological measures.Child and adolescent psychiatry and mental health · 2026Article
- Frequency of bullying modulates amygdala response during social exclusion in participants with non-suicidal self-injury.European child & adolescent psychiatry · 2026Article
- Understanding Depression in Women Across the Lifespan: Hormonal Insights From Brain Imaging.Brain and behavior · 2026Review
- Altered EEG microstate dynamics in adolescents with non-suicidal self-injury at rest and following acute social exclusion.Frontiers in psychiatry · 2026Article
- Motivational-addictive profiles of nonsuicidal self-injury in Chinese youth: a cluster analysis with validation using external correlates.Frontiers in psychiatry · 2026Article
- Structural-functional connectivity decoupling reveals neural differences associated with subtypes of nonsuicidal self-injury among female depressive adolescents.Frontiers in psychiatry · 2026Article
- Research progress on the characteristic features of non-suicidal self-injury addiction, neuroimaging correlates, and evidence-based interventions in adolescents.Frontiers in psychology · 2026Review
- Depressive symptoms and subjective cognitive dysfunction associated with non-suicidal self-injury among Chinese adolescents: the mediating role of impulsivity and the moderating role of addictive features.Frontiers in psychiatry · 2026Article
- Molecular, Structural, and Functional Neuroimaging in Major Depression.Advances in experimental medicine and biology · 2026Review
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Distinct Trajectories of Amygdala Connectivity Patterns Characterize Remission vs. Non-Remission in Patients With Major Depressive Disorder.Depression and anxiety · 2026Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNon-suicidal self-injury (NSSI) is a significant mental health problem among adolescents. Research is needed to clarify the neurobiology of NSSI and identify candidate neurobiological targets for interventions. Based on prior research implicating heightened negative affect and amygdala hyperactivity in NSSI, we pursued a systems approach to characterize amygdala functional connectivity networks during rest (resting-state functional connectivity [RSFC)]) and a task (task functional connectivity [TFC]) in adolescents with NSSI.
methodWe examined amygdala networks in female adolescents with NSSI and healthy controls (n = 45) using resting-state fMRI and a negative emotion face-matching fMRI task designed to activate the amygdala. Connectivity analyses included amygdala RSFC, amygdala TFC, and psychophysiological interactions (PPI) between amygdala connectivity and task conditions.
resultsCompared to healthy controls, adolescents with NSSI showed atypical amygdala-frontal connectivity during rest and task; greater amygdala RSFC in supplementary motor area (SMA) and dorsal anterior cingulate; and differential amygdala-occipital connectivity between rest and task. After correcting for depression symptoms, amygdala-SMA RSFC abnormalities, among others, remained significant. LIMITATIONS: This study's limitations include its cross-sectional design and its absence of a psychiatric control group.
conclusionsUsing a multi-modal approach, we identified widespread amygdala circuitry anomalies in adolescents with NSSI. While deficits in amygdala-frontal connectivity (driven by depression symptoms) replicates prior work in depression, hyperconnectivity between amygdala and SMA (independent of depression symptoms) has not been previously reported. This circuit may represent an important mechanism underlying the link between negative affect and habitual behaviors. These abnormalities may represent intervention targets for adolescents with NSSI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.