ArticlePLoS genetics2017
Flipping chromosomes in deep-sea archaea.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Ecological and evolutionary implications of a mobile genetic element-rich haloarchaeon with unique osmotic resilience.Microbiology spectrum · 2026Article
- CRISPR spacers reveal diverse and abundant Thermococcales viruses in hydrothermal vents.Research square · 2026Article
- A self-transmissible plasmid from a hyperthermophile that facilitates genetic modification of diverse Archaea.Nature microbiology · 2023Article
- Archaeal tyrosine recombinases.FEMS microbiology reviews · 2021Review
- Metagenomics survey unravels diversity of biogas microbiomes with potential to enhance productivity in Kenya.PloS one · 2021Article
- Extended Archaeal Histone-Based Chromatin Structure Regulates Global Gene Expression inFrontiers in microbiology · 2021Article
- Pervasive Suicidal Integrases in Deep-Sea Archaea.Molecular biology and evolution · 2020Article
- WASPS: web-assisted symbolic plasmid synteny server.Bioinformatics (Oxford, England) · 2020Article
- The global distribution and evolutionary history of the pT26-2 archaeal plasmid family.Environmental microbiology · 2019Article
- Integrated mobile genetic elements in Thaumarchaeota.Environmental microbiology · 2019Article
- Micro-evolution of three Streptococcus species: selection, antigenic variation, and horizontal gene inflow.BMC evolutionary biology · 2019Article
- Evolution of Genome Architecture in Archaea: Spontaneous Generation of a New Chromosome in Haloferax volcanii.Molecular biology and evolution · 2018Article
- A novel family of tyrosine integrases encoded by the temperate pleolipovirus SNJ2.Nucleic acids research · 2018Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the major mechanisms driving the evolution of all organisms is genomic rearrangement. In hyperthermophilic Archaea of the order Thermococcales, large chromosomal inversions occur so frequently that even closely related genomes are difficult to align. Clearly not resulting from the native homologous recombination machinery, the causative agent of these inversions has remained elusive. We present a model in which genomic inversions are catalyzed by the integrase enzyme encoded by a family of mobile genetic elements. We characterized the integrase from Thermococcus nautili plasmid pTN3 and showed that besides canonical site-specific reactions, it catalyzes low sequence specificity recombination reactions with the same outcome as homologous recombination events on DNA segments as short as 104bp both in vitro and in vivo, in contrast to other known tyrosine recombinases. Through serial culturing, we showed that the integrase-mediated divergence of T. nautili strains occurs at an astonishing rate, with at least four large-scale genomic inversions appearing within 60 generations. Our results and the ubiquitous distribution of pTN3-like integrated elements suggest that a major mechanism of evolution of an entire order of Archaea results from the activity of a selfish mobile genetic element.
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