ReviewJournal of neurologic physical therapy : JNPT2017
Consideration of Dose and Timing When Applying Interventions After Stroke and Spinal Cord Injury.
Review in Journal of neurologic physical therapy : JNPT, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Essential training variables of arm-hand training in people with cervical spinal cord injury: a systematic review.Journal of rehabilitation medicine · 2023Pooled it
- Effects of control strategies on gait in robot-assisted post-stroke lower limb rehabilitation: a systematic review.Journal of neuroengineering and rehabilitation · 2022Pooled it
- ENHANCE proof-of-concept three-arm randomized trial: effects of reaching training of the hemiparetic upper limb restricted to the spasticity-free elbow range.Scientific reports · 2023Trial
- Early and intensive Motor Training for people with spinal cord injuries (the SCI-MT Trial): description of the intervention.Spinal cord · 2023Trial
- Patients' experiences while undergoing high-intensity gait training during inpatient stroke rehabilitation: a qualitative study.BMC health services research · 2026Article
- Salidroside promotes the repair of spinal cord injury by inhibiting astrocyte polarization, promoting neural stem cell proliferation and neuronal differentiation.Cell death discovery · 2024Article
- An In Vitro and Ex Vivo Analysis of the Potential of GelMA Hydrogels as a Therapeutic Platform for Preclinical Spinal Cord Injury.Advanced healthcare materials · 2023Article
- Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol.Spinal cord · 2023Article
- Providing Insights into the Challenges of Implementing Activity-Based Therapy in Canada: A Comparative Analysis Using Focus Group Interviews with Key Interest Groups.Topics in spinal cord injury rehabilitation · 2023Article
- Patients' and professionals' perspectives on the consideration of patients' convenient therapy periods as part of personalised rehabilitation: a focus group study with patients and therapists from inpatient neurological rehabilitation.BMC health services research · 2022Article
- Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research.Journal of neurotrauma · 2021Review
- A Review of Robot-Assisted Lower-Limb Stroke Therapy: Unexplored Paths and Future Directions in Gait Rehabilitation.Frontiers in neurorobotics · 2020Review
- Belief, Confidence, and Motivation to Use the Paretic Upper Limb in Daily Life Over the First 24 Weeks After Stroke.Journal of neurologic physical therapy : JNPT · 2019Article
- Principles of Neurorehabilitation After Stroke Based on Motor Learning and Brain Plasticity Mechanisms.Frontiers in systems neuroscience · 2019Review
- Review
- Rationale for Intervention and Dose Is Lacking in Stroke Recovery Trials: A Systematic Review.Stroke research and treatment · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeNearly 4 decades of investigation into the plasticity of the nervous system suggest that both timing and dose could matter. This article provides a synopsis of our lectures at the IV STEP meeting, which presented a perspective of current data on the issues of timing and dose for adult stroke and spinal cord injury motor rehabilitation. SUMMARY OF KEY POINTS: For stroke, the prevailing evidence suggests that greater amounts of therapy do not result in better outcomes for upper extremity interventions, regardless of timing. Whether or not greater amounts of therapy result in better outcomes for lower extremity and mobility interventions needs to be explicitly tested. For spinal cord injury, there is a complex interaction of timing postinjury, task-specificity, and the microenvironment of the spinal cord. Inflammation appears to be a key determinant of whether or not an intervention will be beneficial or maladaptive, and specific retraining of eccentric control during gait may be necessary. RECOMMENDATIONS FOR CLINICAL PRACTICE: To move beyond the limitations of our current interventions and to effectively reach nonresponders, greater precision in task-specific interventions that are well-timed to the cellular environment may hold the key. Neurorehabilitation that ameliorates persistent deficits, attains greater recovery, and reclaims nonresponders will decrease institutionalization, improve quality of life, and prevent multiple secondary complications common after stroke and spinal cord injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.