Observational studyJournal of acquired immune deficiency syndromes (1999)2017
Increased Persistence of Initial Treatment for HIV Infection With Modern Antiretroviral Therapy.
Observational study in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- High effectiveness of recommended first-line antiretroviral therapies in Germany: a nationwide, prospective cohort study.Infection · 2020Trial
- Observational
- Excess Weight Gain With Integrase Inhibitors and Tenofovir Alafenamide: What Is the Mechanism and Does It Matter?Open forum infectious diseases · 2021Review
- Integrase Inhibitor Prescribing Disparities in the DC and Johns Hopkins HIV Cohorts.Open forum infectious diseases · 2021Article
- Real-world adherence and persistence for newly-prescribed HIV treatment: single versus multiple tablet regimen comparison among US medicaid beneficiaries.AIDS research and therapy · 2020Article
- Effectiveness of integrase strand transfer inhibitors among treatment-experienced patients in a clinical setting.AIDS (London, England) · 2019Observational
- Postpartum HIV care continuum outcomes in the southeastern USA.AIDS (London, England) · 2019Article
- Treatment Adherence And Persistence Among HIV-1 Patients Newly Starting Treatment.Patient preference and adherence · 2019Article
- New antiretroviral agent use affects prevalence of HIV drug resistance in clinical care populations.AIDS (London, England) · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInitiating antiretroviral therapy (ART) early improves clinical outcomes and prevents transmission. Guidelines for first-line therapy have changed with the availability of newer ART agents. In this study, we compared persistence and virologic responses with initial ART according to the class of anchor agent used.
settingAn observational clinical cohort study in the Southeastern United States.
methodsAll HIV-infected patients participating in the UNC Center for AIDS Research Clinical Cohort (UCHCC) and initiating ART between 1996 and 2014 were included. Separate time-to-event analyses with regimen discontinuation and virologic failure as outcomes were used, including Kaplan-Meier survival curves and adjusted Cox proportional hazards models.
resultsOne thousand six hundred twenty-four patients were included (median age of 37 years at baseline, 28% women, 60% African American, and 28% white). Eleven percent initiated integrase strand transfer inhibitor (INSTI), 33% non-nucleoside reverse transcriptase inhibitor (NNRTI), 20% boosted protease inhibitor, 27% other, and 9% NRTI only regimens. Compared with NNRTI-containing regimens, INSTI-containing regimens had an adjusted hazard ratio of 0.49 (95% confidence interval, 0.35 to 0.69) for discontinuation and 0.70 (95% confidence interval, 0.46 to 1.06) for virologic failure. All other regimen types were associated with increased rates of discontinuation and failure compared with NNRTI.
conclusionsInitiating ART with an INSTI-containing regimen was associated with lower rates of regimen discontinuation and virologic failure.
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