Evidence map›Paper›PMID 28628128›Full record

ArticleNature methods2017

Adaptive optics improves multiphoton super-resolution imaging.

Wei Zheng, Yicong Wu, Peter Winter, Robert Fischer, Damian Dalle Nogare, Amy Hong, Chad McCormick, Ryan Christensen, William P Dempsey, Don B Arnold and 5 more

Abstract readVideo-Audio Media
In one paragraph

Article in Nature methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Live-cell imaging powered by computation.Nature reviews. Molecular cell biology · 2024
    Review
  14. Article
  15. Adaptive optics for optical microscopy [Invited].Biomedical optics express · 2023
    Review
  16. Review
  17. Multiscale fluorescence imaging of living samples.Histochemistry and cell biology · 2022
    Review
  18. Review
  19. Article
  20. Answering some questions about structured illumination microscopy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wei ZhengSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0001-6107-7261
Yicong WuSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Peter WinterSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Robert FischerNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Damian Dalle NogareEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Amy HongNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chad McCormickEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Ryan ChristensenSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
William P DempseyDepartment of Biology, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA.
Don B ArnoldDepartment of Biology, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, California, USA.
Joshua ZimmerbergEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0002-1707-3789
Ajay ChitnisEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
James SellersNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Clare WatermanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Hari ShroffSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Mechanical Regulation of Cell AdhesionZIAHL005104 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WATERMAN, CLARE MICHAL · 2009 to 2025
$30.9M
Mechanisms and Intracellular Components in Exocytosis, Membrane Assembly and Repair, and Parasite ReplicationZIAHD001415 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ZIMMERBERG, JOSHUA · 2009 to 2025
$26.0M
Integration of Actin Dynamics and Adhesion in Cell MigrationZIAHL005105 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI WATERMAN, CLARE MICHAL · 2009 to 2025
$16.5M
Section on High Resolution Optical ImagingZIAEB000074 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI SHROFF, HARI · 2010 to 2022
$15.2M
Expression Studies of Other Unconventional MyosinsZIAHL004232 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SELLERS, JAMES · 2009 to 2025
$11.7M
Dynamic mapping of the complete synaptome using recombinant probesR01MH107238 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARNOLD, DONALD B, FRASER, SCOTT E · 2014 to 2018
$9.7M
Intramural NIH HHS ZIA EB000074NIMH NIH HHS R01 MH107238
6 · The paper itself

Abstract

We improve multiphoton structured illumination microscopy using a nonlinear guide star to determine optical aberrations and a deformable mirror to correct them. We demonstrate our method on bead phantoms, cells in collagen gels, nematode larvae and embryos, Drosophila brain, and zebrafish embryos. Peak intensity is increased (up to 40-fold) and resolution recovered (up to 176 ± 10 nm laterally, 729 ± 39 nm axially) at depths ∼250 μm from the coverslip surface.

Indexed as

LensesEquipment DesignEquipment Failure AnalysisFeedbackImage EnhancementMicroscopy, Fluorescence, MultiphotonReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID28628128
PMCPMC7749710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.