SynthesisNature genetics2017
Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 10 pooled it
20.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
121 citing papers in PubMed, 10 syntheses or guidelines pooled it, 258 citations in OpenAlex.
- Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects.Nature communications · 2026Pooled it
- Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy.Human reproduction (Oxford, England) · 2023Pooled it
- Polygenic prediction of preeclampsia and gestational hypertension.Nature medicine · 2023Pooled it
- Pooled it
- Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications biology · 2021Pooled it
- The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.Immunity · 2021Pooled it
- The genetic architecture of sporadic and multiple consecutive miscarriage.Nature communications · 2020Pooled it
- Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.Nature communications · 2020Pooled it
- A review of omics approaches to study preeclampsia.Placenta · 2020Pooled it
- Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: a meta-analysis.Archives of gynecology and obstetrics · 2018Pooled it
- Gene regulation at the early human maternal-fetal interface.Nature reviews. Genetics · 2026Review
- Observational
- Transforming Preeclampsia Care: Molecular Diagnostics and Therapeutic Innovations.Journal of the American Society of Nephrology : JASN · 2026Review
- The endothelin-1/TLR4/NF-κB/NLRP3 inflammasome axis in preeclampsia: a review of a pathological feed-forward loop and therapeutic frontier.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Understanding Preeclampsia: Integrating Placental Dysfunction, Immune Dysregulation and microRNA-Mediated Epigenetic Regulation.International journal of molecular sciences · 2026Review
- Esomeprazole Decreases Soluble Fms-like Tyrosine Kinase-1 in Preeclamptic Pregnancy in Rats.International journal of molecular sciences · 2026Article
- Revised Two-Stage Model of Preeclampsia Based on Autophagic Dysfunction: A Comprehensive Review.Biomolecules · 2026Review
- Genetics and Stillbirth.Clinics in perinatology · 2026Review
- Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health.International journal of epidemiology · 2026Article
- Both Fetal and Maternal Genotypes Affect Preeclampsia Pathogenesis in Iranian Patients.Biochemical genetics · 2026Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 19 institutions in 8 countries.
Ralph McGinnisWellcome Trust Sanger Institute, Cambridge, UK.
Valgerdur SteinthorsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Nicholas O WilliamsWellcome Trust Sanger Institute, Cambridge, UK.
Gudmar ThorleifssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Scott ShooterWellcome Trust Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-9822-7964
Sigrun HjartardottirDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland.
Suzannah BumpsteadWellcome Trust Sanger Institute, Cambridge, UK.
Lilja StefansdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Lucy HildyardWellcome Trust Sanger Institute, Cambridge, UK.
Jon K SigurdssondeCODE Genetics/Amgen, Reykjavik, Iceland.
John P KempMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-9105-2249
Gabriela B SilvaCentre of Molecular Inflammation Research (CEMIR) and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Liv Cecilie V ThomsenCentre of Molecular Inflammation Research (CEMIR) and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Tiina JääskeläinenMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Eero KajantieNational Institute for Health and Welfare, Helsinki, Finland.
Sally ChappellSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Noor KalshekerSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Ashley MoffettDepartment of Pathology, University of Cambridge, Cambridge, UK.
Susan HibyDepartment of Pathology, University of Cambridge, Cambridge, UK.
Wai Kwong LeeBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Sandosh PadmanabhanBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Nigel A B SimpsonLeeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.
Vivien A DolbyLeeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.
Eleonora Staines-UriasDepartment of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Stephanie M EngelDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Anita HauganNorwegian Institute of Public Health, Oslo, Norway.
Lill TrogstadNorwegian Institute of Public Health, Oslo, Norway.
Gulnara SvyatovaScientific Center of Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan.
Nodira ZakhidovaInstitute of Immunology, Uzbek Academy of Sciences, Tashkent, Uzbekistan.
Dilbar NajmutdinovaRepublic Specialized Scientific Practical Medical Centre of Obstetrics and Gynecology, Tashkent, Uzbekistan.
FINNPEC Consortium
GOPEC Consortium
Anna F DominiczakBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-4913-3608
Håkon K GjessingNorwegian Institute of Public Health, Oslo, Norway.
Juan P CasasFarr Institute of Health Informatics, University College London, London, UK.
Frank DudbridgeDepartment of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
James J WalkerLeeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-8922-083X
Fiona Broughton PipkinMedical School, University of Nottingham, Nottingham, UK.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Reykjavik, Iceland.
Reynir T GeirssonDepartment of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland.
Debbie A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
Ann-Charlotte IversenCentre of Molecular Inflammation Research (CEMIR) and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0001-7726-7684
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.
Hannele LaivuoriMedical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3212-7826
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Linda MorganSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-2995-4081
deCODE Genetics (Iceland) · ISWellcome Sanger Institute · GBNorwegian Institute of Public Health · NOUniversity of Nottingham · GBNorwegian University of Science and Technology · NOUniversity of Glasgow · GBUniversity of Helsinki · FIUniversity of Leeds · GBReykjavík University · ISUniversity of Cambridge · GBAcademy of Sciences Republic of Uzbekistan · UZFarr Institute · GBKazakh Institute of Oncology and Radiology · KZLondon School of Hygiene & Tropical Medicine · GBNuffield Orthopaedic Centre · GBTashkent Pediatric Medical Institute · UZTranslational Research Institute · AUUniversity of Bristol · GBUniversity of North Carolina at Chapel Hill · US
Funding
Prenatal Smoking, Maternal & Fetal Genetic Variation & Risk of PreeclampsiaR01HD058008 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ENGEL, STEPHANIE · 2008 to 2012
$2.7MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/5NICHD NIH HHS R01 HD058008
Abstract
Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10
Indexed as
FetusGenetic Predisposition to DiseaseCohort StudiesFemaleFollow-Up StudiesGenome, HumanGenome-Wide Association StudyGenotypeHumansPolymorphism, Single NucleotidePre-EclampsiaPregnancyPregnancy ProteinsVascular Endothelial Growth Factor Receptor-1FLT1 protein, humanPregnancy ProteinsVascular Endothelial Growth Factor Receptor-1
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.