ArticleNature microbiology2017
Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.
Abstract read
In one paragraph
Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
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Corrections and comments
- Commented on byCommentary:2017
Authors and funding
16 authors at 5 institutions in 3 countries.
Manlio Di CristinaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.ORCID http://orcid.org/0000-0003-4154-5210
Zhicheng DouDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Matteo LunghiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06122, Italy.
Geetha KannanDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
My-Hang HuynhDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Olivia L McGovernDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Tracey L SchultzDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Aric J SchultzDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Alyssa J MillerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Beth M HayesDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Wouter van der LindenDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia 06122, Italy.
Matthew BogyoDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Sébastien BesteiroDIMNP-UMR 5235 CNRS, Université de Montpellier, 34095 Montpellier Cedex 5, France.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.ORCID http://orcid.org/0000-0001-6859-8895
University of Michigan · USUniversity of Perugia · ITStanford University · USCentre National de la Recherche Scientifique · FRJohns Hopkins University · US
Funding
Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3MThe role of acetate fermentation in Entamoeba histolytica growth and infectionP20GM109094 · NIGMS · CLEMSON UNIVERSITY · PI PAUL, KIMBERLY SUE · 2016 to 2020
$10.4MMolecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8MTargeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1MParasite autophagy as a key survival mechanism for the AIDS-associated pathogen Toxoplasma gondiiR01AI120607 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2016 to 2025
$4.0MEquipment supplement for Chemical methods to study protein palmitoylation pathwaysR01GM111703 · NIGMS · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2014 to 2017
$1.6MTrafficking of host proteins into Toxoplasma via a novel ingestion pathwayF31AI118274 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCGOVERN, OLIVIA LAUREN · 2015 to 2016
$69kNIAID NIH HHS F31 AI118274NIAID NIH HHS R01 AI060767NIAID NIH HHS R01 AI120607NIAID NIH HHS T32 AI007528NIDCR NIH HHS T32 DE007057NIGMS NIH HHS P20 GM109094NIGMS NIH HHS R01 GM111703
Abstract
Globally, nearly 2 billion people are infected with the intracellular protozoan Toxoplasma gondii
Indexed as
Host-Pathogen InteractionsAnimalsAutophagosomesCells, CulturedCell SurvivalCysteine ProteasesFibroblastsGene Knockout TechniquesHumansLysosomesMice, Inbred C57BLNeuronsProteolysisProtozoan ProteinsToxoplasmaCysteine ProteasesProtozoan Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.