ArticleJournal of neural engineering2017
A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.
Article in Journal of neural engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Transcutaneous vagus nerve stimulation as a pain modulator in knee osteoarthritis: a randomized controlled clinical trial.BMC musculoskeletal disorders · 2025Trial
- Bioelectronic Medicines-A Novel Approach of Therapeutics in Current Epoch.Current pharmaceutical design · 2025Review
- Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice.Nature communications · 2024Article
- Recent Advancements in Bioelectronic Medicine: A Review.Current drug delivery · 2024Review
- Hybrid Bionic Nerve Interface for Application in Bionic Limbs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Fractal Microelectrodes for More Energy-Efficient Cervical Vagus Nerve Stimulation.Advanced healthcare materials · 2023Article
- Impact of Non-Pharmacological Interventions on the Mechanisms of Atherosclerosis.International journal of molecular sciences · 2022Review
- A Microclip Peripheral Nerve Interface (μcPNI) for Bioelectronic Interfacing with Small Nerves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Neuromodulation Strategies to Reduce Inflammation and Improve Lung Complications in COVID-19 Patients.Frontiers in neurology · 2022Review
- Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine.Bioelectronic medicine · 2021Article
- Development and characterization of a chronic implant mouse model for vagus nerve stimulation.eLife · 2021Article
- Direct measurement of vagal tone in rats does not show correlation to HRV.Scientific reports · 2021Article
- How is flexible electronics advancing neuroscience research?Biomaterials · 2021Review
- Optogenetic Manipulation of the Vagus Nerve.Advances in experimental medicine and biology · 2021Article
- A Focused Review of Neural Recording and Stimulation Techniques With Immune-Modulatory Targets.Frontiers in immunology · 2021Review
- Inflammation neuroscience: neuro-immune crosstalk and interfaces.Clinical & translational immunology · 2021Review
- Intraneural ultramicroelectrode arrays for function-specific interfacing to the vagus nerve.Biosensors & bioelectronics · 2020Article
- Recent progress on peripheral neural interface technology towards bioelectronic medicine.Bioelectronic medicine · 2020Review
- Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory Disease.Cold Spring Harbor perspectives in medicine · 2020Review
- Neural reflex control of vascular inflammation.Bioelectronic medicine · 2020Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveNeural reflexes regulate immune responses and homeostasis. Advances in bioelectronic medicine indicate that electrical stimulation of the vagus nerve can be used to treat inflammatory disease, yet the understanding of neural signals that regulate inflammation is incomplete. Current interfaces with the vagus nerve do not permit effective chronic stimulation or recording in mouse models, which is vital to studying the molecular and neurophysiological mechanisms that control inflammation homeostasis in health and disease. We developed an implantable, dual purpose, multi-channel, flexible 'microelectrode' array, for recording and stimulation of the mouse vagus nerve. APPROACH: The array was microfabricated on an 8 µm layer of highly biocompatible parylene configured with 16 sites. The microelectrode was evaluated by studying the recording and stimulation performance. Mice were chronically implanted with devices for up to 12 weeks. MAIN
resultsUsing the microelectrode in vivo, high fidelity signals were recorded during physiological challenges (e.g potassium chloride and interleukin-1β), and electrical stimulation of the vagus nerve produced the expected significant reduction of blood levels of tumor necrosis factor (TNF) in endotoxemia. Inflammatory cell infiltration at the microelectrode 12 weeks of implantation was limited according to radial distribution analysis of inflammatory cells. SIGNIFICANCE: This novel device provides an important step towards a viable chronic interface for cervical vagus nerve stimulation and recording in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.