Evidence map›Paper›PMID 28627942›Full record

ArticleBrain injury2017

Diffusion imaging of mild traumatic brain injury in the impact accelerated rodent model: A pilot study.

Zora Kikinis, Marc Muehlmann, Ofer Pasternak, Sharon Peled, Praveen Kulkarni, Craig Ferris, Sylvain Bouix, Yogesh Rathi, Inga K Koerte, Steve Pieper and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain injury, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. A multiscale tissue assessment in a rat model of mild traumatic brain injury.Journal of neuropathology and experimental neurology · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Lifespan Trajectories of White Matter Changes in Rhesus Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Zora Kikinisa Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Marc Muehlmanna Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Ofer Pasternaka Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Sharon Peledc Department of Radiology , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Praveen Kulkarnid Center for Translational NeuroImaging, Department of Psychology , Northeastern University , Boston , MA , USA.
Craig Ferrisd Center for Translational NeuroImaging, Department of Psychology , Northeastern University , Boston , MA , USA.
Sylvain Bouixa Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Yogesh Rathia Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Inga K Koertea Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Steve Piepere Isomics, Inc ., Cambridge , MA , USA.
Alexander Yarmarkoviche Isomics, Inc ., Cambridge , MA , USA.
Caryn L Porterf Department of Neurosurgery , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Bruce S Kristalf Department of Neurosurgery , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Martha E Shentona Psychiatry Neuroimaging Laboratory, Department of Psychiatry , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
Brigham and Women's Hospital · USHarvard University · USNortheastern University · US

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSDR01HD090641 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN · 2016 to 2018
$810k
NIBIB NIH HHS P41 EB015902NICHD NIH HHS R01 HD090641
6 · The paper itself

Abstract

PRIMARY

objectiveThere is a need to understand pathologic processes of the brain following mild traumatic brain injury (mTBI). Previous studies report axonal injury and oedema in the first week after injury in a rodent model. This study aims to investigate the processes occurring 1 week after injury at the time of regeneration and degeneration using diffusion tensor imaging (DTI) in the impact acceleration rat mTBI model. RESEARCH

designEighteen rats were subjected to impact acceleration injury, and three rats served as sham controls. Seven days post injury, DTI was acquired from fixed rat brains using a 7T scanner. Group comparison of Fractional Anisotropy (FA) values between traumatized and sham animals was performed using Tract-Based Spatial Statistics (TBSS), a method that we adapted for rats. MAIN OUTCOMES AND

resultsTBSS revealed white matter regions of the brain with increased FA values in the traumatized versus sham rats, localized mainly to the contrecoup region. Regions of increased FA included the pyramidal tract, the cerebral peduncle, the superior cerebellar peduncle and to a lesser extent the fibre tracts of the corpus callosum, the anterior commissure, the fimbria of the hippocampus, the fornix, the medial forebrain bundle and the optic chiasm.

conclusionSeven days post injury, during the period of tissue reparation in the impact acceleration rat model of mTBI, microstructural changes to white matter can be detected using DTI.

Indexed as

Diffusion Tensor ImagingAnimalsAnisotropyBrain ConcussionMaleModels, AnimalNerve RegenerationPilot ProjectsRatsRats, Sprague-DawleyWhite MatterAnimal modeldiffusion tensor magnetic resonance imaging (dMRI)fractional anisotropy (FA)impact acceleration injurymild traumatic brain injury (mTBI)

Identifiers

PMID28627942
PMCPMC5896003
OpenAlexW2659925573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.