Evidence map›Paper›PMID 28627812›Full record

ArticleGenes, brain, and behavior2017

Genetics of alcohol consumption in Drosophila melanogaster.

S Fochler, T V Morozova, M R Davis, A W Gearhart, W Huang, T F C Mackay, R R H Anholt

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Ethanol resistance inEcology and evolution · 2021
    Article
  10. Article
  11. Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations ofProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Review
  14. Flying Together:International journal of molecular sciences · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. AG3 (Bethesda, Md.) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

S FochlerW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
T V MorozovaW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
M R DavisW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
A W GearhartW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
W HuangW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
T F C MackayW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
R R H AnholtW. M. Keck Center for Behavioral Biology, Program in Genetics, and Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0001-7196-8324

Funding

Molecular Genetics of Olfaction in DrosophiliaR01GM059469 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ANHOLT, ROBERT R. H, MACKAY, TRUDY F. · 1999 to 2016
$5.8M
Genetics of Alcohol Sensitivity in DrosophilaR01AA016560 · NIAAA · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ANHOLT, ROBERT R. H, MACKAY, TRUDY F. · 2007 to 2016
$4.0M
NIAAA NIH HHS R01 AA016560NIGMS NIH HHS R01 GM059469
6 · The paper itself

Abstract

Individual variation in alcohol consumption in human populations is determined by genetic, environmental, social and cultural factors. In contrast to humans, genetic contributions to complex behavioral phenotypes can be readily dissected in Drosophila, where both the genetic background and environment can be controlled and behaviors quantified through simple high-throughput assays. Here, we measured voluntary consumption of ethanol in ∼3000 individuals of each sex from an advanced intercross population derived from 37 lines of the Drosophila melanogaster Genetic Reference Panel. Extreme quantitative trait loci mapping identified 385 differentially segregating allelic variants located in or near 291 genes at P < 10

Indexed as

Gene Regulatory NetworksQuantitative Trait LociAlcohol DrinkingAnimalsDrosophila melanogasterDrosophila ProteinsFemaleGenetic BackgroundMalePolymorphism, Single NucleotideSex FactorsDrosophila ProteinsAdvanced intercrossbehavioral geneticsCAFÉ assayDrosophila melanogaster Genetic Reference Panelextreme QTL mappingfeeding behaviorfunctional genomicsmutational analysisnetworkRNAisingle nucleotide polymorphismtranslational genomics

Identifiers

PMID28627812
PMCPMC5667673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.