ArticleLab on a chip2017
Controlled self-assembly of alginate microgels by rapidly binding molecule pairs.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses.Advanced healthcare materials · 2026Review
- Brick by Brick the Wall Is Being Built: Particle-Based Scaffolds for Regenerative Medicine.Polymers · 2025Review
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
- Indenting at the Microscale: Guidelines for Robust Mechanical Characterization of Alginate Microgels.ACS applied materials & interfaces · 2025Article
- Surface-Functionalized Microgels as Artificial Antigen-Presenting Cells to Regulate Expansion of T Cells.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Hierarchical Design of Tissue-Mimetic Fibrillar Hydrogel Scaffolds.Advanced healthcare materials · 2024Review
- Towards single cell encapsulation for precision biology and medicine.Advanced drug delivery reviews · 2023Review
- The application and prospects of 3D printable microgel in biomedical science and engineering.International journal of bioprinting · 2023Review
- Microgel assembly: Fabrication, characteristics and application in tissue engineering and regenerative medicine.Bioactive materials · 2022Review
- Matrix biophysical cues direct mesenchymal stromal cell functions in immunity.Acta biomaterialia · 2021Review
- Magnetic microgels and nanogels: Physical mechanisms and biomedical applications.Bioengineering & translational medicine · 2021Review
- Dynamic Click Hydrogels for Xeno-Free Culture of Induced Pluripotent Stem Cells.Advanced biosystems · 2020Article
- Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments.Advanced functional materials · 2020Article
- Preparation and evaluation of microfluidic magnetic alginate microparticles for magnetically templated hydrogels.Journal of colloid and interface science · 2020Article
- Natural-Based Biomaterials for Peripheral Nerve Injury Repair.Frontiers in bioengineering and biotechnology · 2020Review
- Microfluidic Encapsulation of Single Cells by Alginate Microgels Using a Trigger-Gellified Strategy.Frontiers in bioengineering and biotechnology · 2020Article
- Effects of Sodium Alginate on the Flotation Separation of Molybdenite From Chalcopyrite Using Kerosene as Collector.Frontiers in chemistry · 2020Article
- Porous Alginate Scaffolds Assembled Using Vaterite CaCOMicromachines · 2019Review
- Multifunctional laminarin microparticles for cell adhesion and expansion.Carbohydrate polymers · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
Controlled self-assembly of cell-encapsulating microscale polymeric hydrogels (microgels) could be advantageous in a variety of tissue engineering and regenerative medicine applications. Here, a method of assembly by chemical modification of alginate polymer with binding pair molecules (BPM) was explored. Alginate was modified with several types of BPM, specifically biotin and streptavidin and click chemistry compounds, and fabricated into 25-30 μm microgels using a microfluidic platform. These microgels were demonstrated to self-assemble under physiological conditions. By combining complementary microgels at a high ratio, size-defined assemblages were created, and the effects of BPM type and assembly method on the number of microgels per assemblage and packing density were determined. Furthermore, a magnetic process was developed to separate assemblages from single microgels, and allow formation of multilayer spheroids. Finally, cells were singly encapsulated into alginate microgels and assembled using BPM-modified alginate, suggesting potential applications in regenerative medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.