Evidence map›Paper›PMID 28627474›Full record

ArticleBone2017

Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone.

Xinjun He, Sofia Bougioukli, Brandon Ortega, Eric Arevalo, Jay R Lieberman, Andrew P McMahon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. The Periosteum in Health and Disease.Current osteoporosis reports · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Requirement of Pdgfrα+ cells for calvarial bone repair.Stem cells translational medicine · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. TheJBMR plus · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinjun HeDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad-CIRM Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sofia BougioukliDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brandon OrtegaDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Eric ArevaloDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jay R LiebermanDepartment of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad-CIRM Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: amcmahon@med.usc.edu.
University of Southern California · US

Funding

The Roles of BMP Genes and Morphogenesis of the Appendicular and Dermal SkeletonsP01DK056246 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DEMAY, MARIE, KRONENBERG, HENRY M. · 1999 to 2015
$19.3M
NIDDK NIH HHS P01 DK056246
6 · The paper itself

Abstract

introductionThe phases of fracture healing have been well characterized. However, the exact source and genetic profile of the skeletal progenitors that participate in bone repair is somewhat unclear. Sox9 expression in skeletal elements precedes bone and cartilage formation and a Sox9

methodsTo test this hypothesis we used tamoxifen (TM)-mediated lineage tracing of Sox9

resultsIn the intact adult mouse femur, Td-Tomato-labeled cells were observed in the primary spongiosa, periosteum and endosteum. RNA sequencing showed that Td-Tomato positive periosteal cells were co-enriched for Sox9 transcripts, and mRNAs for osteoblast and chondrocyte specific genes. In a femoral fracture model, we showed that pre-labeled Td-Tomato positive descendent cells were mobilized during the early stages of bone repair (day 3 post-op) contributing to the fracture repair process by differentiating into chondrocytes, osteoblasts and osteocytes.

conclusionA Sox9

Indexed as

AnimalsChondrocytesFracture HealingMiceMice, TransgenicOsteoblastsPeriosteumSOX9 Transcription FactorStem CellsSox9 protein, mouseSOX9 Transcription FactorFracture healingPeriosteal cellsSkeletal progenitorsSox9

Identifiers

PMID28627474
PMCPMC6435293
OpenAlexW2626342377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.