ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Post-traumatic stress disorder and risk of dementia among members of a health care delivery system.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Assessing neurocognitive outcomes in PTSD: a multilevel meta-analytical approach.European journal of psychotraumatology · 2025Pooled it
- The Potential Contribution of Chronic Pain and Common Chronic Pain Conditions to Subsequent Cognitive Decline, New Onset Cognitive Impairment, and Incident Dementia: A Systematic Review and Conceptual Model for Future Research.Journal of Alzheimer's disease : JAD · 2020Pooled it
- History of anxiety, depression, and post-traumatic stress disorder diagnoses among midlife and older transfeminine and transmasculine adults in the United States: A cross-sectional analysis within the STRONG cohort.Journal of affective disorders · 2026Article
- Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study.Health science reports · 2026Article
- A longitudinal study of CLDN5 DNA methylation and PTSD.Journal of behavioral medicine · 2026Article
- State of the Science: The epidemiology of posttraumatic stress disorder.Journal of traumatic stress · 2026Review
- Post-traumatic stress disorder and cardiometabolic dysfunction: Molecular mechanisms and therapeutic targets.iScience · 2026Review
- The Role of Posttraumatic Stress Disorder as a Risk Factor for Dementia: A Meta-Analysis.Journal of geriatric psychiatry and neurology · 2026Review
- Alzheimer's disease and related dementias among transfeminine adults: A cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations of war-related exposures and early life adversity with late-life cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Distinct Symptom Profiles in Younger and Older Patients With Cancer Receiving Chemotherapy.Cancer medicine · 2026Article
- Childhood trauma and cognitive decline in women: an empirical analysis of cognitive vulnerability in later life.Frontiers in aging neuroscience · 2026Article
- Posttraumatic stress disorder, major depression, and mild cognitive impairment: A cohort study of world trade center responders.Psychiatry research · 2026Article
- Disaster-related home loss, mental health, and risk of cognitive disability: causal mediation analysis using longitudinal data of disaster survivors.American journal of epidemiology · 2025Article
- Impact of adverse childhood experiences, post-traumatic stress disorder, dissociative disorders, and depression on dementia risk: a prospective analysis of associations and mediation in the UK Biobank cohort.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Quantifying the independent impact of social determinants of health and posttraumatic stress disorder on resource utilization and health outcomes in civilians.Psychiatry research · 2025Article
- War Trauma and Strength: A Qualitative Study of Participants in the Vietnamese Insights into Cognitive Aging Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Risk Predictors and Cognitive Outcomes of the Psychosocial Functioning of North American Older Adults During the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2025Article
- Experimental laboratory models as tools for understanding modifiable dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults.Frontiers in aging neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPost-traumatic stress disorder (PTSD) is associated with an increased risk of dementia in male veterans, but little is known in females and civilians.
methodsPTSD and comorbidities were abstracted from medical records from 1/1/1996 to 12/31/2001. Dementia incidence from 1/1/2002 to 12/31/2014 in 499,844 health care members aged 60+ years over an average of 8.2 years. Cox proportional hazard models were adjusted for age, demographics, and comorbidities.
resultsPTSD was associated with increased risk of dementia over an average of 8 years of follow-up (females: hazard ratio [HR] = 1.59, 95% confidence interval [CI] = 1.30-1.95; males: HR = 1.96, 95% CI = 1.51-2.55). There was a two-fold risk of dementia in those with both PTSD and depression (females: HR = 2.08; 95% CI = 1.66-2.59; males: HR = 2.06; 95% CI = 1.47-2.91) versus those without. DISCUSSION: PTSD was a risk factor for dementia in both sexes, with a heightened risk in those with comorbid depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.