ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Risk of dementia or cognitive impairment in COPD patients: A meta-analysis of cohort studies.Frontiers in aging neuroscience · 2022Pooled it
- Development and validation of a novel predictive model for dementia risk in middle-aged and elderly depression individuals: a large and longitudinal machine learning cohort study.Alzheimer's research & therapy · 2025Article
- Multisystem failure, tipping points, and risk of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of the digital clock drawing test with amyloid and tau PET biomarkers in low age risk adults.Scientific reports · 2025Article
- Development and validation of a dynamic nomogram for predicting cognitive impairment risk in older adults with dentures: analysis from CHARLS and CLHLS data.BMC geriatrics · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Associations of Mid- and Late-Life Fasting Blood Glucose Levels With Dementia Risk Among Patients With Diabetes: Framingham Heart Study.European journal of neurology · 2025Article
- Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people.BMC geriatrics · 2024Article
- Article
- Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias.Neurology · 2023Article
- Modifiable cardiovascular risk factors and genetics for targeted prevention of dementia.European heart journal · 2023Article
- Predicting Alzheimer's Disease and Related Dementias in Heart Failure and Atrial Fibrillation.The American journal of medicine · 2023Article
- Dementia Risk Models in an Australian First Nations Population: Cross-Sectional Associations and Preparation for Follow-Up.Journal of Alzheimer's disease reports · 2023Article
- Modified dementia risk score as a tool for the prediction of dementia: a prospective cohort study of 239745 participants.Translational psychiatry · 2022Article
- Development of a Clinical Risk Score Prediction Tool for 5-, 9-, and 13-Year Risk of Dementia.JAMA network open · 2022Article
- Machine Learning Reveals a Multipredictor Nomogram for Diagnosing the Alzheimer's Disease Based on Chemiluminescence Immunoassay for Total Tau in Plasma.Frontiers in aging neuroscience · 2022Article
- Derivation and validation of the Rapid Assessment of Dementia Risk (RADaR) for older adults.PloS one · 2022Article
- Derivation and Validation of the Cognitive Impairment Prediction Model in Older Adults: A National Cohort Study.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionWith a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. We created a practical dementia risk score and provided individualized estimates of future dementia risk.
methodsUsing the Framingham Heart Study data, we built our prediction model using Cox proportional hazard models and developed a point system for the risk score and risk estimates.
resultsThe score system used total points ranging from -1 to 31 and stratifies individuals into different levels of risk. We estimated 5-, 10-, and 20-year dementia risk prediction and incorporated these into the points system. DISCUSSION: This risk score system provides a practical tool because all included predictors are easy to assess by practitioners. It can be used to estimate future probabilities of dementia for individuals.
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