Evidence map›Paper›PMID 28627374›Full record

ArticleNeuroscience letters2017

Characterization of the concurrent metabolic changes in brain and plasma during insulin-induced moderate hypoglycemia using

Kathleen Ennis, Elizabeth Lusczek, Raghavendra Rao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kathleen EnnisDivision of Neonatology, Department of Pediatrics, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA. Electronic address: enni0012@umn.edu.
Elizabeth LusczekDepartment of Surgery, University of Minnesota, Mayo Mail Code 195, 420 Delaware Street, SE, Minneapolis, MN 55455, USA. Electronic address: lusc0006@umn.edu.
Raghavendra RaoDivision of Neonatology, Department of Pediatrics, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA; Center for Neurobehavioral Development, University of Minnesota, Mayo Mail Code 39, 420 Delaware Street, SE, Minneapolis, MN 55455, USA. Electronic address: raghurao@umn.edu.
University of Minnesota · US

Funding

In vivo Substrate Utilization in the Newborn Rat BrainK08HD047276 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI RAO, RAGHAVENDRA B · 2004 to 2006
$371k
NICHD NIH HHS K08 HD047276
6 · The paper itself

Abstract

Treatment of hypoglycemia in children is currently based on plasma glucose measurements. This approach may not ensure neuroprotection since plasma glucose does not reflect the dynamic state of cerebral energy metabolism. To determine whether cerebral metabolic changes during hypoglycemia could be better characterized using plasma metabolomic analysis, insulin-induced acute hypoglycemia was induced in 4-week-old rats. Brain tissue and concurrent plasma samples were collected from hypoglycemic (N=7) and control (N=7) rats after focused microwave fixation to prevent post-mortem metabolic changes. The concentration of 29 metabolites in brain and 34 metabolites in plasma were determined using

Indexed as

MetabolomeAnimalsBrainDisease Models, AnimalFemaleHypoglycemiaMalePlasmaProton Magnetic Resonance SpectroscopyRatsRats, Sprague-Dawley(1)H NMR spectroscopyBrainHypoglycemiaMetabolomicsPlasmaRat

Identifiers

PMID28627374
PMCPMC13075481
OpenAlexW2626213595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.