Evidence map›Paper›PMID 28627133›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2017

Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors.

Daniel O Claassen, Adam J Stark, Charis A Spears, Kalen J Petersen, Nelleke C van Wouwe, Robert M Kessler, David H Zald, Manus J Donahue

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
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  3. Impulse control and related behavioral disorders in Parkinson's disease. Risk factors, diagnosis, and management. Is there a possible role for non-invasive brain stimulation?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  13. Management of psychiatric disorders in Parkinson's disease : Neurotherapeutics - Movement Disorders Therapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  14. Article
  15. The Neuropsychiatry of Parkinson Disease: A Perfect Storm.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
    Review
  16. Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel O ClaassenNeurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Adam J StarkNeurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Charis A SpearsNeurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kalen J PetersenNeurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nelleke C van WouweNeurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Robert M KesslerRadiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David H ZaldPsychiatry, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Manus J DonahueNeurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt University Medical Center · USUniversity of Alabama at Birmingham · USVanderbilt Health · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Biological Determinants of Impulsivity in Parkinson's DiseaseR01NS097783 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER · 2016 to 2020
$2.2M
Dopamine Effects on Mesocorticolimbic Function in Parkinson DiseaseK23NS080988 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAASSEN, DANIEL OLIVER · 2013 to 2017
$904k
Radiofluorination Equipment for PET Imaging ResearchS10OD019963 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2016 to 2016
$291k
NCATS NIH HHS UL1 TR000445NINDS NIH HHS K23 NS080988NINDS NIH HHS R01 NS097783
6 · The paper itself

Abstract

backgroundPD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation.

objectivesWe tested the hypothesis that dopamine agonists differentially alter mesocortical and mesolimbic network activity in patients with impulsive-compulsive behaviors.

methodsDopamine agonist effects on neuronal metabolism were quantified using arterial-spin-labeling MRI measures of cerebral blood flow in the on-dopamine agonist and off-dopamine states. The within-subject design included 34 PD patients, 17 with active impulsive compulsive behavior symptoms, matched for age, sex, disease duration, and PD severity.

resultsPatients with impulsive-compulsive behaviors have a significant increase in ventral striatal cerebral blood flow in response to dopamine agonists. Across all patients, ventral striatal cerebral blood flow on-dopamine agonist is significantly correlated with impulsive-compulsive behavior severity (Questionnaire for Impulsive Compulsive Disorders in Parkinson's Disease- Rating Scale). Voxel-wise analysis of dopamine agonist-induced cerebral blood flow revealed group differences in mesocortical (ventromedial prefrontal cortex; insular cortex), mesolimbic (ventral striatum), and midbrain (SN; periaqueductal gray) regions.

conclusionsThese results indicate that dopamine agonist therapy can augment mesocorticolimbic and striato-nigro-striatal network activity in patients susceptible to impulsive-compulsive behaviors. Our findings reinforce a wider literature linking studies of maladaptive behaviors to mesocorticolimbic networks and extend our understanding of biological mechanisms of impulsive compulsive behaviors in PD. © 2017 International Parkinson and Movement Disorder Society.

Indexed as

Cerebral CortexPeriaqueductal GrayVentral StriatumAgedAnimalsCerebrovascular CirculationDopamine AgonistsFemaleHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseaseSeverity of Illness IndexSpin LabelsDopamine AgonistsSpin Labelscerebral blood flowdopamineimpulse control disorderimpulsive compulsive behaviorsParkinson's disease

Identifiers

PMID28627133
PMCPMC5681361
OpenAlexW2626002889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.