Evidence map›Paper›PMID 28627017›Full record

ArticleThe Journal of physiology2017

Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.

Wei-Chun Wei, Wan-Chen Huang, Yu-Ping Lin, Esther B E Becker, Olaf Ansorge, Veit Flockerzi, Daniele Conti, Giovanna Cenacchi, Maike D Glitsch

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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  14. Alterations in the CaExploration of targeted anti-tumor therapy · 2021
    Article
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  17. Article
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  19. GPR68: An Emerging Drug Target in Cancer.International journal of molecular sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Wei-Chun WeiDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Wan-Chen HuangDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Yu-Ping LinDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Esther B E BeckerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Olaf AnsorgeNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
Veit FlockerziExperimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany.
Daniele ContiDepartment of Biomedical and Neuromotor Science, University of Bologna, Italy.
Giovanna CenacchiDepartment of Biomedical and Neuromotor Science, University of Bologna, Italy.
Maike D GlitschDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.ORCID 0000-0003-0723-3117
University of Oxford · GBUniversity of Bologna · ITSaarland University · DE

Funding

Biotechnology and Biological Sciences Research Council BB/1008748/1Medical Research Council MR/L022656/1
6 · The paper itself

Abstract

key pointsThe proton sensing ovarian cancer G protein coupled receptor 1 (OGR1, aka GPR68) promotes expression of the canonical transient receptor potential channel subunit TRPC4 in normal and transformed cerebellar granule precursor (DAOY) cells. OGR1 and TRPC4 are prominently expressed in healthy cerebellar tissue throughout postnatal development and in primary cerebellar medulloblastoma tissues. Activation of TRPC4-containing channels in DAOY cells, but not non-transformed granule precursor cells, results in prominent increases in [Ca ABSTRACT: Aberrant intracellular Ca

Indexed as

AnimalsCalciumCalcium SignalingCell Line, TumorCell MovementCells, CulturedCerebellumHumansMedulloblastomaMice, Inbred C57BLNeuronsPermeabilityReceptors, G-Protein-CoupledTRPC Cation ChannelsCalciumGPR68 protein, humanReceptors, G-Protein-CoupledTRPC4 ion channelTRPC Cation ChannelscerebellummedulloblastomaOGR1proton sensing G protein coupled receptorsTransient Receptor Potential ChannelsTRPC4

Identifiers

PMID28627017
PMCPMC5556167
OpenAlexW2635217538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.