Evidence map›Paper›PMID 28626813›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2016

Hallucinations as top-down effects on perception.

Albert R Powers, Megan Kelley, Philip R Corlett

Registry-linked trialAbstract read
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04210557 (Models of Auditory Hallucination), which is not on this map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04210557 naterminatednot on this mapstarted 2020, after this paper: background citation

Models of Auditory Hallucination

TypeinterventionalSponsorYale UniversityRan2020 to 2021Enrolled1ConditionsSchizophrenia, Schizo Affective Disorder, Auditory HallucinationArmsTranscranial Magnetic Stimulation (TMS)
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Albert R PowersDepartment of Psychiatry, Yale University.
Megan KelleyDepartment of Psychiatry, Yale University.
Philip R CorlettDepartment of Psychiatry, Yale University.

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Clinical Neuroscience Research Training Program in PsychiatryT32MH019961 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 1996 to 2026
$5.9M
Pathophysiology of Auditory HallucinationsR01MH067073 · NIMH · YALE UNIVERSITY · PI CORLETT, PHILIP · 2003 to 2015
$3.0M
NCATS NIH HHS UL1 TR000142NIMH NIH HHS R01 MH067073NIMH NIH HHS T32 MH019961
6 · The paper itself

Abstract

The problem of whether and how information is integrated across hierarchical brain networks embodies a fundamental tension in contemporary cognitive neuroscience, and by extension, cognitive neuropsychiatry. Indeed, the penetrability of perceptual processes in a 'top-down' manner by higher-level cognition-a natural extension of hierarchical models of perception-may contradict a strictly modular view of mental organization. Furthermore, some in the cognitive science community have challenged cognitive penetration as an unlikely, if not impossible, process. We review the evidence for and against top-down influences in perception, informed by a predictive coding model of perception and drawing heavily upon the literature of computational neuroimaging. We extend these findings to propose a way in which these processes may be altered in mental illness. We propose that hallucinations - perceptions without stimulus - can be understood as top-down effects on perception, mediated by inappropriate perceptual priors.

Indexed as

ConnectivityHallucinationsModularityNeuroimagingNeuropsychologyPredictive CodingPsychosis

Identifiers

PMID28626813
PMCPMC5469545

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.