Evidence map›Paper›PMID 28626605›Full record

ArticlePeerJ2017

No relationship between vertebral column shifts and limb fluctuating asymmetry in human foetuses.

Clara M A Ten Broek, Jessica Bots, Marianna Bugiani, Frietson Galis, Stefan Van Dongen

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Clara M A Ten BroekNaturalis Biodiversity Center, Leiden, Netherlands.
Jessica BotsEvolutionary Ecology Group, Department of Biology, Universiteit Antwerpen, Wilrijk, Antwerp, Belgium.
Marianna BugianiDepartment of Pathology, VU Medical Center, Amsterdam, Netherlands.
Frietson GalisNaturalis Biodiversity Center, Leiden, Netherlands.
Stefan Van DongenEvolutionary Ecology Group, Department of Biology, Universiteit Antwerpen, Wilrijk, Antwerp, Belgium.
Naturalis Biodiversity Center · NLUniversity of Antwerp · BEAmsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disturbance from the normal developmental trajectory of a trait during growth-the so-called developmental instability-can be observed morphologically through phenodeviants and subtle deviations from perfect symmetry (fluctuating asymmetry). This study investigates the relationship between phenodeviance in the human vertebral column (as a result of axial patterning defects) and limb fluctuating asymmetry. Since both types of markers of developmental instability have been found associated with congenital abnormalities in humans, we anticipate a relationship between them if the concept of developmental instability, measured through either phenodeviants or asymmetry, would reflect an organism-wide process. Yet we did not find any support for this hypothesis. We argue that the vast differences in the developmental processes involved in both systems renders these two markers of developmental instability unrelated, in spite of their associations with other congenital abnormalities. Our results thus contribute to the growing awareness that developmental instability is not an organism-wide property.

Indexed as

Birth defectsCervical ribCongenital abnormalitiesDevelopmental instabilityFluctuating asymmetryMarkerPatterning deffectsVertebral column shifts

Identifiers

PMID28626605
PMCPMC5470575
OpenAlexW2626744054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.