Evidence map›Paper›PMID 28626572›Full record

ArticleChemical science2017

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone.

Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H F Fine, Andreas Friebe, Martin Zacharias, David J Hodson and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Fine-tuned photochromic sulfonylureas for optical control of beta cell CaDiabetic medicine : a journal of the British Diabetic Association · 2023
    Article
  2. Photoswitchable Probes of Oxytocin and Vasopressin.Journal of medicinal chemistry · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Tom PodewinDepartment of Chemistry and Center for Integrated Protein Science , LMU Munich , Butenandtstr. 5-13 , 81377 Munich , Germany . Email: anja.hoffmann-roeder@cup.lmu.de ; Email: dirk.trauner@cup.lmu.de.ORCID 0000-0002-1632-5104
Johannes BroichhagenDepartment of Chemistry and Center for Integrated Protein Science , LMU Munich , Butenandtstr. 5-13 , 81377 Munich , Germany . Email: anja.hoffmann-roeder@cup.lmu.de ; Email: dirk.trauner@cup.lmu.de.ORCID 0000-0003-3084-6595
Christina FrostDepartment of Physics , Technical University of Munich , James-Franck-Str. 1 , 85748 Garching , Germany.ORCID 0000-0002-6581-027X
Dieter GronebergJulius-Maximilian-University Würzburg , Institute of Physiology , Röntgenring 9 , 97070 Würzburg , Germany.ORCID 0000-0001-9673-433X
Julia AstInstitute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE) , University of Birmingham , Edgbaston , B15 2TT , UK.ORCID 0000-0002-0039-4762
Helena Meyer-BergDepartment of Chemistry and Center for Integrated Protein Science , LMU Munich , Butenandtstr. 5-13 , 81377 Munich , Germany . Email: anja.hoffmann-roeder@cup.lmu.de ; Email: dirk.trauner@cup.lmu.de.ORCID 0000-0001-6435-7584
Nicholas H F FineInstitute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE) , University of Birmingham , Edgbaston , B15 2TT , UK.ORCID 0000-0003-2343-8534
Andreas FriebeJulius-Maximilian-University Würzburg , Institute of Physiology , Röntgenring 9 , 97070 Würzburg , Germany.ORCID 0000-0001-8178-3948
Martin ZachariasDepartment of Physics , Technical University of Munich , James-Franck-Str. 1 , 85748 Garching , Germany.ORCID 0000-0001-5163-2663
David J HodsonInstitute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE) , University of Birmingham , Edgbaston , B15 2TT , UK.ORCID 0000-0002-8641-8568
Dirk TraunerDepartment of Chemistry and Center for Integrated Protein Science , LMU Munich , Butenandtstr. 5-13 , 81377 Munich , Germany . Email: anja.hoffmann-roeder@cup.lmu.de ; Email: dirk.trauner@cup.lmu.de.ORCID 0000-0002-6782-6056
Anja Hoffmann-RöderDepartment of Chemistry and Center for Integrated Protein Science , LMU Munich , Butenandtstr. 5-13 , 81377 Munich , Germany . Email: anja.hoffmann-roeder@cup.lmu.de ; Email: dirk.trauner@cup.lmu.de.ORCID 0000-0002-8352-8323
Center for Integrated Protein Science Munich · DELaboratoire de Biologie Physico-Chimique des Protéines Membranaires · FRMax Planck Computing and Data Facility · DEStiftung Juliusspital · DE

Funding

European Research Council 268795Medical Research Council MR/N00275X/1Wellcome Trust
6 · The paper itself

Abstract

The optical control over biological function with small photoswitchable molecules has gathered significant attention in the last decade. Herein, we describe the design and synthesis of a small library of photoswitchable peptidomimetics based upon human atrial natriuretic peptide (ANP), in which the photochromic amino acid [3-(3-aminomethyl)phenylazo]phenylacetic acid (AMPP) is incorporated into the peptide backbone. The endogeneous hormone ANP signals

Identifiers

PMID28626572
PMCPMC5471452
OpenAlexW2605386427

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.