ReviewFrontiers in aging neuroscience2017
Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management.
Review in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06918847 (Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.A RCT), which is not on this map. Cited by 78 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.A RCT
Who cites it
78 citing papers in PubMed, 8 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Neuromodulation for Restless Legs Syndrome: A Systematic Review and Mechanistic Considerations for Spinal Cord Stimulation.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- The association between restless legs syndrome and chronic venous insufficiency: a systematic review.Journal of medicine and life · 2025Pooled it
- The Effect of Superficial Heat-Cold Application on the Sleep Quality of Patients With Restless Leg Syndrome: A Systematic Review and Meta-Analysis.Nursing open · 2024Pooled it
- Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.Nutrients · 2024Pooled it
- The global and regional prevalence of restless legs syndrome among adults: A systematic review and modelling analysis.Journal of global health · 2024Pooled it
- Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.Communications biology · 2021Pooled it
- Improvement of restless leg syndrome in maintenance hemodialysis patients with limb ischemic preconditioning: a single-center randomized controlled clinical trial.Renal failure · 2023Trial
- Trial
- Selective impairment of affective theory of mind in restless legs syndrome: a case-control study.Arquivos de neuro-psiquiatria · 2026Article
- Hypoxia-Associated Remodeling of the Arginine-Citrulline-Ornithine Axis in Parkinson's Disease and Restless Legs Syndrome: A Targeted LC-MS/MS and HIF-1α Profiling Study.Medicina (Kaunas, Lithuania) · 2026Article
- Effect of Cannabinoids use on Symptoms of Restless Leg Syndrome among Adults: A Scoping Review.Annals of Indian Academy of Neurology · 2026Article
- Sympathetic Activation and Sleep-Related Movements: Integrating Autonomic, Dopaminergic, and Iron Deficiency Mechanisms.Brain sciences · 2026Review
- Association between lesion location and symptoms of restless leg syndrome (RLS) among patients with multiple sclerosis (MS).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Restless legs syndrome in children with celiac disease: associations with vitamin D and iron deficiency and the role of gluten-free diet adherence.BMC pediatrics · 2026Article
- Prevalence, risk factors, and clinical impact of restless leg syndrome on uremia patients with hemodialysis.Frontiers in neurology · 2026Article
- Restless legs syndrome and inflammatory bowel disease: A systematic review and meta-analysis.IBRO neuroscience reports · 2025Article
- Sleep disturbances linked to plasma orexin A levels in patients with bipolar disorder: A preliminary study.Comprehensive psychoneuroendocrinology · 2025Article
- Restless legs syndrome in Parkinson's disease: epidemiology, pathogenetic overlaps, and clinical management.Journal of neurology · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western countries, has gained more and more attention in Asian countries. The prevalence of RLS is higher in older people and females. RLS is most commonly related to iron deficiency, pregnancy and uremia. The RLS symptoms show a significant circadian rhythm and a close relationship to periodic limb movements (PLMs) in clinical observations, while the pathophysiological pathways are still unknown. The diagnostic criteria have been revised in 2012 to improve the validity of RLS diagnosis. Recent studies have suggested an important role of iron decrease of brain in RLS pathophysiology. Dopaminergic (DA) system dysfunction in A11 cell groups has been recognized long ago from clinical treatment and autopsy. Nowadays, it is believed that iron dysfunction can affect DA system from different pathways and opioids have a protective effect on DA system. Several susceptible single nucleotide polymorphisms such as BTBD9 and MEIS1, which are thought to be involved in embryonic neuronal development, have been reported to be associated with RLS. Several pharmacological and non-pharmacological treatment are discussed in this review. First-line treatments of RLS include DA agents and α2δ agonists. Augmentation is very common in long-term treatment of RLS which makes prevention and management of augmentation very important for RLS patients. A combination of different types of medication is effective in preventing and treating augmentation. The knowledge on RLS is still limited, the pathophysiology and better management of RLS remain to be discovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.