ArticleFrontiers in neuroscience2017
Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss.International journal of molecular sciences · 2026Review
- Auditory brainstem response audiometry in tauopathy mouse model of human Alzheimer's disease.JASA express letters · 2024Article
- Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.The Journal of the Acoustical Society of America · 2024Article
- Maintained Spatial Learning and Memory Functions in Middle-Aged α9 Nicotinic Receptor Subunit Knock-Out Mice.Brain sciences · 2023Article
- Sources of variability in auditory brainstem response thresholds in a mouse model of noise-induced hearing loss.The Journal of the Acoustical Society of America · 2022Article
- Physiological Evidence for Delayed Age-related Hearing Loss in Two Long-lived Rodent Species (Peromyscus leucopus and P. californicus).Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Auditory Behavior in Adult-Blinded Mice.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Olivocochlear Changes Associated With Aging Predominantly Affect the Medial Olivocochlear System.Frontiers in neuroscience · 2021Article
- Linking anatomical and physiological markers of auditory system degeneration with behavioral hearing assessments in a mouse (Mus musculus) model of age-related hearing loss.Neurobiology of aging · 2020Article
- Efferent Inhibition of the Cochlea.Cold Spring Harbor perspectives in medicine · 2019Review
- Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Reflex Modification Audiometry Reveals Dual Roles for Olivocochlear Neurotransmission.Frontiers in cellular neuroscience · 2017Article
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Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Studies have suggested a role of weakened medial olivocochlear (OC) efferent feedback in accelerated hearing loss and increased susceptibility to noise. The present study investigated the progression of hearing loss with age and exposure to a noisy environment in medial OC-deficient mice. Alpha9 nicotinic acetylcholine receptor knockout (α9KO) and wild types were screened for hearing loss using auditory brainstem responses. α9KO mice housed in a quiet environment did not show increased hearing loss compared to wild types in young adulthood and middle age. Challenging the medial OC system by housing in a noisy environment did not increase hearing loss in α9KO mice compared to wild types. ABR wave 1 amplitudes also did not show differences between α9KO mice and wild types. These data suggest that deficient medial OC feedback does not result in early onset of hearing loss.
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Registered trials
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