Evidence map›Paper›PMID 28626237›Full record

ArticleCellular & molecular immunology2018

CD4+ T cells memorize obesity and promote weight regain.

Jianghuan Zou, Beibei Lai, Mingzhu Zheng, Qin Chen, Shujun Jiang, Anying Song, Zan Huang, Peiliang Shi, Xin Tu, Di Wang and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04436419 (Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04436419 nacompletednot on this map

Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity: Translational Study

TypeinterventionalSponsorFauquéRan2018 to 2020Enrolled40ConditionsObesity, Obesity, Abdominal, Obesity, Visceral, FemaleArmsAlpha lipoic acid (plus full hospitalization), Placebo (full hospitalization: dietary monitoring with an adapted physical activity program)
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Developmental origins of immunometabolic health.Immunometabolism (Cobham, Surrey) · 2026
    Review
  11. Article
  12. Weight Loss-Associated Remodeling of Adipose Tissue Immunometabolism.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  13. Article
  14. Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  15. Article
  16. Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Transient Dietary Intervention Induces Healthy Adipose Tissue Expansion and Metabolically Healthy Obesity in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianghuan ZouState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Beibei LaiState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Mingzhu ZhengInstitute of Immunology, Program in Molecular and Cellular Biology, Zhejiang University School of Medicine, 310058, Hangzhou, China, Zhejiang.
Qin ChenState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Shujun JiangState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Anying SongState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Zan HuangState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Peiliang ShiState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Xin TuState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Di WangInstitute of Immunology, Program in Molecular and Cellular Biology, Zhejiang University School of Medicine, 310058, Hangzhou, China, Zhejiang.
Linrong LuInstitute of Immunology, Program in Molecular and Cellular Biology, Zhejiang University School of Medicine, 310058, Hangzhou, China, Zhejiang.
Zhaoyu LinState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu.
Xiang GaoState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, 12 Xuefu Road, Pukou District, 210061, Nanjing, China, Jiangsu. gaoxiang@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown. In this study, we report that immune cells, especially CD4+ T cells, mediate the 'memory' of previous obese status. In a weight gain-loss-regain model, we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain. This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice. Surprisingly, such obesity memory was abrogated by dexamethasone treatment, whereas immunodeficient Rag1

Indexed as

Immunologic MemoryAnimalsBasal MetabolismCD4-Positive T-LymphocytesHyperphagiaMice, Inbred C57BLObesityThermogenesisWeight GainWeight Loss

Identifiers

PMID28626237
PMCPMC6079001

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.