ReviewAmerican journal of physiology. Heart and circulatory physiology2017
Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease.
Review in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04419727 (Molecular Analysis of Estrogen Receptors in Patients With Peripheral Artery Disease), which is not on this map. Cited by 107 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Analysis of Estrogen Receptors in Patients With Peripheral Artery Disease
Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neighborhood walkability and sex steroid hormone levels in women.Environmental research · 2022Pooled it
- Sex differences in endothelial glycocalyx thickness and the response to glycocalyx-targeted therapy among older adults.Physiological reports · 2025Trial
- Sex steroid hormones and subclinical atherosclerosis progression in postmenopausal women.European journal of endocrinology · 2025Trial
- Effect of Combined Physical Exercise Training in Reducing Cardiovascular Risk Among Adults with Obesity: A Randomized Clinical Trial.Journal of prevention (2022) · 2024Trial
- Sex differences in endothelial function in chronic kidney disease.American journal of physiology. Renal physiology · 2020Trial
- Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.Acta biomaterialia · 2026Article
- Article
- Comparative Analysis of Streptozotocin, Streptozotocin-Nicotinamide and Alloxan-Based Diabetes Models in Female Wistar Rats.Methods and protocols · 2026Article
- Temporal trends in cardiac arrest and cancer-related mortality among adults in the United States, 1999-2023.Cardio-oncology (London, England) · 2026Article
- Development and validation of an Occupational Hazards Index (OHI) and its association with hypertension-diabetes comorbidity in steel workers: a prospective cohort study.BMC public health · 2026Article
- Trimethylamine N-oxide is elevated in postmenopausal women relative to age-matched men and premenopausal women among individuals with obesity.Experimental physiology · 2026Article
- Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure.Annual review of physiology · 2026Review
- The multisystem impact of perimenopausal hormonal fluctuations on chronic disease risk.Frontiers in endocrinology · 2026Review
- Innate immunity and hypertension: unveiling inflammatory pathways for novel therapies.Frontiers in pharmacology · 2026Review
- Review
- Article
- Blood pressure indices for predicting incident cardiovascular disease: A 13-year follow-up study in Japanese population.American journal of preventive cardiology · 2025Article
- The hyperaemic and metaboreflex response of the diaphragm during fatiguing diaphragmatic work in humans.The Journal of physiology · 2025Article
- Unveiling the Sex-Based Divide: Exploring Sex Differences in Peripheral Artery Disease.Current atherosclerosis reports · 2025Review
- Toward Sex-Specific Biomaterials Innovation: A Perspective.ACS biomaterials science & engineering · 2025Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sex differences between women and men are often overlooked and underappreciated when studying the cardiovascular system. It has been long assumed that men and women are physiologically similar, and this notion has resulted in women being clinically evaluated and treated for cardiovascular pathophysiological complications as men. Currently, there is increased recognition of fundamental sex differences in cardiovascular function, anatomy, cell signaling, and pathophysiology. The National Institutes of Health have enacted guidelines expressly to gain knowledge about ways the sexes differ in both normal function and diseases at the various research levels (molecular, cellular, tissue, and organ system). Greater understanding of these sex differences will be used to steer future directions in the biomedical sciences and translational and clinical research. This review describes sex-based differences in the physiology and pathophysiology of the vasculature, with a special emphasis on sex steroid receptor (estrogen and androgen receptor) signaling and their potential impact on vascular function in health and diseases (e.g., atherosclerosis, hypertension, peripheral artery disease, abdominal aortic aneurysms, cerebral aneurysms, and stroke).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.