Evidence map›Paper›PMID 28626072›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

5-HT causes splanchnic venodilation.

Bridget M Seitz, Hakan S Orer, Teresa Krieger-Burke, Emma S Darios, Janice M Thompson, Gregory D Fink, Stephanie W Watts

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Guidelines for authors and reviewers on antibody use in physiology studies.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Development of a 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  9. 5-HTMicrocirculation (New York, N.Y. : 1994) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Activation of the 5-HTExperimental physiology · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Hypertension exhibits 5-HTHypertension research : official journal of the Japanese Society of Hypertension · 2019
    Article
  20. Statistical considerations in reporting cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Bridget M SeitzDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and.
Hakan S OrerDepartment of Pharmacology, School of Medicine, Koc University, Istanbul, Turkey.
Teresa Krieger-BurkeDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and.
Emma S DariosDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and.
Janice M ThompsonDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and.
Gregory D FinkDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and.
Stephanie W WattsDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and wattss@msu.edu.ORCID http://orcid.org/0000-0002-9653-6357
Michigan State University · USKoç University · TR

Funding

Vascular and Neural Mechanisms of Serotonin-induced Reduction in Blood PressureR01HL107495 · NHLBI · MICHIGAN STATE UNIVERSITY · PI WATTS, STEPHANIE W · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL107495
6 · The paper itself

Abstract

Serotonin [5-hydroxytryptamine (5-HT)] causes relaxation of the isolated superior mesenteric vein, a splanchnic blood vessel, through activation of the 5-HT

Indexed as

AnimalsArterial PressureDose-Response Relationship, DrugInfusions, IntravenousIn Vitro TechniquesMaleMesenteric VeinsPortal VeinRats, Sprague-DawleyReceptors, SerotoninSerotoninSerotonin AntagonistsSerotonin Receptor AgonistsSplanchnic CirculationTelemetryTime FactorsReceptors, SerotoninSerotoninserotonin 7 receptorSerotonin AntagonistsSerotonin Receptor AgonistsVasodilator Agentsblood pressureimagingpharmacologySB-269970serotoninveins

Identifiers

PMID28626072
PMCPMC5625177
OpenAlexW2625327938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.