Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans.
Open access · bronzeAbstract readClinical Trial
In one paragraph
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans.Anesthesiology · 2020Trial
- Acupuncture-induced changes in locus coeruleus connectivity and memory improvement in patients with amnestic cognitive impairment.IBRO neuroscience reports · 2026Article
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- The role of the salience network in adolescent impulsivity using memory tasks and neuroimaging.Communications medicine · 2025Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.Scientific reports · 2025Article
- Studies in rats of a target specific and reversible general anesthetic with a favorable safety profile.PloS one · 2025Article
- Article
- Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings.Handbook of experimental pharmacology · 2024Review
- The Effect of Dexmedetomidine Sedation on Lower Gastrointestinal Motility in Children-Is It Suitable for Anorectal Manometry?Journal of clinical medicine · 2023Article
- Locus coeruleus activity while awake is associated with REM sleep quality in older individuals.JCI insight · 2023Article
- Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea.Scientific reports · 2023Article
- The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation.Frontiers in neuroscience · 2023Article
- Dexmedetomidine Ameliorated Cognitive Dysfunction Induced by Intestinal Ischemia Reperfusion in Mice with Possible Relation to the Anti-inflammatory Effect Through the Locus Coeruleus Norepinephrine System.Neurochemical research · 2022Article
- Functional Connectivity Disturbances of the Locus Coeruleus in Chronic Insomnia Disorder.Nature and science of sleep · 2022Article
- The effects of dexmedetomidine for patient-controlled analgesia on postoperative sleep quality and gastrointestinal motility function after surgery: A prospective, randomized, double-blind, and controlled trial.Frontiers in pharmacology · 2022Article
- Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System.Current neuropharmacology · 2022Review
- Article
- Article
- Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Andrew H SongDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Aaron KucyiDepartment of Neurology, Stanford University Medical Center, Stanford, California 94305.ORCID 0000-0001-6707-0028
Vitaly NapadowDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129.ORCID 0000-0003-1941-1750
Emery N BrownDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02144, and.ORCID 0000-0003-2668-7819
Marco L LoggiaDepartment of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, oluwaseun.akeju@mgh.harvard.edu marco@nmr.mgh.harvard.edu.ORCID 0000-0002-8026-5265
Oluwaseun AkejuDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02144, and oluwaseun.akeju@mgh.harvard.edu marco@nmr.mgh.harvard.edu.ORCID 0000-0002-6740-1250
Harvard University · USMassachusetts Institute of Technology · US
Funding
The Role of Context Effect in Acupuncture Treatment of Low Back/J.KongP01AT006663 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, ROSEN, BRUCE R · 2011 to 2017
$10.0MProject 4: Mathematical Modeling Studies of Anesthetic ActionP01GM118269 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 2017 to 2021
$9.0MRedesigning General Anesthesia (Admin Supp)R01GM104948 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., BROWN, EMERY N · 2012 to 2016
$4.4MBrain Mechanisms Underlying CBT-Related Reductions in FibromyalgiaR01AR064367 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R, NAPADOW, VITALY · 2014 to 2018
$4.0MPathophysiology of postoperative delirium and the use of biomimetic sleep as a treatment strategy in the CSICUR01AG053582 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHNSON-AKEJU, OLUWASEUN · 2016 to 2020
$4.0MThe Role of Brain Glial Activation in knee OstoarthritisR01NS094306 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2016 to 2020
$3.5MNeuroimaging Approaches to Deconstructing Acupuncuture for Chronic PainR01AT007550 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARRIS, RICHARD E, NAPADOW, VITALY · 2013 to 2019
$3.4MMapping the linkage between auricular vagus nerve receptors and cardiovagal modulationOT2OD023867 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY · 2016 to 2021
$3.4MOptimization of brain-based mechanisms supporting psychosocial aspects of acupuncture therapy - a hyperscanning fMRI studyR61AT009306 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KAPTCHUK, TED, NAPADOW, VITALY · 2016 to 2017
$959kNCCIH NIH HHS P01 AT006663NCCIH NIH HHS R01 AT007550NCCIH NIH HHS R61 AT009306NIAMS NIH HHS R01 AR064367NIA NIH HHS R01 AG053582NIGMS NIH HHS P01 GM118269NIGMS NIH HHS R01 GM104948NIH HHS OT2 OD023867NINDS NIH HHS R01 NS094306
Abstract
State-dependent activity of locus ceruleus (LC) neurons has long suggested a role for noradrenergic modulation of arousal. However,
Indexed as
AdolescentAdrenergic alpha-2 Receptor AgonistsAdrenergic NeuronsAdultArousalConnectomeDexmedetomidineFemaleHumansHypnotics and SedativesLocus CoeruleusMagnetic Resonance ImagingMaleNerve NetNeural PathwaysNeuronal PlasticityAdrenergic alpha-2 Receptor AgonistsDexmedetomidineHypnotics and Sedativesaltered arousaldexmedetomidinefunctional connectivitylocus ceruleusnoradrenergic arousal circuitposterior cingulate cortex
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.