ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Effects of Ventral Striatum Lesions on Stimulus-Based versus Action-Based Reinforcement Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Foraging models explain human exploration in uncertain tasks.Nature communications · 2026Article
- Perceptual response patterns in rhesus macaque attentional set shifting are associated with inflexible behavior.Cognitive, affective & behavioral neuroscience · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Contribution of amygdala to dynamic model arbitration under uncertainty.Nature communications · 2025Article
- Neural correlates of trial outcome monitoring during long-term learning in primate posterior parietal cortex.Nature communications · 2025Article
- Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity.Nature communications · 2025Article
- Non-invasive Ultrasonic Neuromodulation of the Human Nucleus Accumbens Impacts Reward Sensitivity.bioRxiv : the preprint server for biology · 2025Article
- From avoidance to new action: the multifaceted role of the striatal indirect pathway.Nature reviews. Neuroscience · 2025Review
- Four Streams Within the Prefrontal Cortex: Integrating Structural and Functional Connectivity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.Neuron · 2024Article
- Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Computational Mechanisms Underlying Motivation to Earn Symbolic Reinforcers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- An opponent striatal circuit for distributional reinforcement learning.bioRxiv : the preprint server for biology · 2024Article
- The motivational role of the ventral striatum and amygdala in learning from gains and losses.Behavioral neuroscience · 2023Article
- Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys.Cognitive, affective & behavioral neuroscience · 2023Article
- Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys.Biological psychiatry global open science · 2023Article
- Anterior cingulate cortex causally supports flexible learning under motivationally challenging and cognitively demanding conditions.PLoS biology · 2022Article
- Reinforcement-learning in fronto-striatal circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Learning the values of actions versus stimuli may depend on separable neural circuits. In the current study, we evaluated the performance of rhesus macaques with ventral striatum (VS) lesions on a two-arm bandit task that had randomly interleaved blocks of stimulus-based and action-based reinforcement learning (RL). Compared with controls, monkeys with VS lesions had deficits in learning to select rewarding images but not rewarding actions. We used a RL model to quantify learning and choice consistency and found that, in stimulus-based RL, the VS lesion monkeys were more influenced by negative feedback and had lower choice consistency than controls. Using a Bayesian model to parse the groups' learning strategies, we also found that VS lesion monkeys defaulted to an action-based choice strategy. Therefore, the VS is involved specifically in learning the value of stimuli, not actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.